Uninterrupted prolonged ethanol oxidation as a main pathogenetic factor of alcoholic liver damage: evidence from a new liquid diet animal model.
Uninterrupted prolonged ethanol oxidation as a main pathogenetic factor of alcoholic liver damage: evidence from a new liquid diet animal model.
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不间断的长时间乙醇氧化是酒精性肝损伤的主要致病因素：来自新流质饮食动物模型的证据。
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
M. Salaspuro
中科院分区：
文献类型：
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作者：
K. Lindros;L. Stowell;H. Väänänen;P. Sipponen;U. Lamminsivu;P. Pikkarainen;M. Salaspuro
在营养充足和平衡的液体乙醇饮食维持12周的大鼠肝脏中观察到明显的脂肪浸润和退行性或轻度炎症变化，包括小叶中心细胞中的嗜酸性细胞质变性和伴细胞坏死的局灶性炎症变化。由于饲料中补充了低剂量的4-甲基吡唑（4-MP，一种醇脱氢酶抑制剂），动物持续氧化乙醇，使乙醇消除减少约20%。在接受（a）不含4-MP的类似含乙醇液体饲料或（B）含4-MP和20%乙醇的饲料的其他等比例成对喂养大鼠组中，仅观察到一些微小变化。大鼠的肝脏组织学配对喂养的对照饮食与4倍高剂量的4-MP是完全正常的。结果表明，由于乙醇的不间断氧化导致的肝脏代谢的长期失衡是酒精性肝损伤发展的关键因素。
Marked fatty infiltration and degenerative or mild inflammatory changes including eosinophilic cytoplasmic degeneration in centrilobular cells and focal inflammatory changes with cell necrosis were observed in livers of rats maintained for 12 weeks on a nutritionally adequate and balanced liquid ethanol diet. The animals continuously oxidized ethanol due to the supplementation of the diet with a low dose of 4-methylpyrazole (4-MP, an alcohol dehydrogenase inhibitor), that decreased ethanol elimination by about 20%. In other, equicalorically pair-fed groups of rats receiving (a) a similar ethanol-containing liquid diet without 4-MP or (b) a diet with 4-MP and 20% less ethanol, only a few minor changes were seen. The liver histology of rats pair-fed a control diet with a 4 times higher doses of 4-MP was completely normal. The results indicate that the prolonged imbalance of hepatic metabolism due to the uninterrupted oxidation of ethanol is a crucial factor in the development of alcoholic liver injury.