Effect of Age and Sex mismatched Normal Database on Diagnostic Performance of 18F-FDG PET for Alzheimer's Disease: The Ishikawa Brain Imaging Study
Effect of Age and Sex mismatched Normal Database on Diagnostic Performance of 18F-FDG PET for Alzheimer's Disease: The Ishikawa Brain Imaging Study
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年龄和性别不匹配的正常数据库对 18F-FDG PET 阿尔茨海默病诊断性能的影响：石川脑成像研究
DOI：
10.1097/mnm.0b013e32834b43c2
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Matsunari I
中科院分区：
文献类型：
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作者：
Chen WP;Samuraki M;Shima K;Yanase D;Nozomi;Takeda N;Miyazaki Y;Ono K;Yoshita M;Nishimura S;Yamada M;Matsunari I
目标18 F-FDG PET 结合基于体素的统计图像分析在阿尔茨海默病 (AD) 的诊断中发挥着重要作用。然而，年龄匹配和性别匹配或不匹配的正常数据库（NDB）对 18 F-FDG PET 诊断性能的影响尚未得到系统研究。本研究的目的是确定使用 18 F-FDG PET 检测 AD 是否需要年龄匹配和性别匹配的 NDB。方法我们为 18 F-FDG PET 生成了 11 个 NDB 集，其中包括 6 个由 20 岁至 70 岁参与者组成的特定年龄 NDB 集、1 个年龄非特定 NDB 集、1 个年龄匹配 NDB 集、2 个特定性别 NDB 集，每个集由 20 名参与者组成男性或 20 名女性，以及一组性别匹配的 NDB 组。使用这些 NDB 集计算 PET 图像中预定义的 AD 特定感兴趣区域的平均 z 分数，并进行接收者操作特征分析以评估 18 F-FDG PET 的诊断性能，以区分 46 名 AD 患者和 50 名正常对照。结果使用年龄匹配/不匹配的 NDB 集或性别匹配/不匹配的 NDB 集，接收者操作特征曲线下的每个区域没有显着差异。 18 F-FDG PET 的诊断性能对 NDB 中的年龄或性别差异相当不敏感，这表明精确的年龄匹配或性别匹配的 NDB 对于使用 18 F-FDG PET 区分 AD 患者和正常参与者可能并不重要。
Objectives18 F-FDG PET with voxel-based statistical image analysis plays an important role in the diagnosis of Alzheimer’s disease (AD). However, the effect of an age-matched and sex-matched or mismatched normal database (NDB) on the diagnostic performance of 18 F-FDG PET has not yet been investigated systematically. The aim of this study was to determine whether an age-matched and sex-matched NDB is necessary for the detection of AD using 18 F-FDG PET.MethodsWe generated 11 NDB sets for 18 F-FDG PET, including six age-specific NDB sets consisting of participants ranging in age from 20 to 70 years, one age-non-specific NDB set, one age-matched NDB set, two sex-specific NDB sets, each consisting of 20 men or 20 women, and one sex-matched NDB set. The average z-scores in predefined AD-specific regions of interest of the PET images were calculated using those NDB sets and a receiver-operating characteristic analysis was carried out to assess the diagnostic performance of 18 F-FDG PET to discriminate 46 patients with AD from 50 normal controls.ResultsThere was no significant difference in each area under the receiver-operating characteristic curve using either age-matched/mismatched NDB sets or sex-matched/mismatched NDB sets.ConclusionThe diagnostic performance of 18 F-FDG PET was rather insensitive to differences in age or sex in the NDB, indicating that exact age-matched or sex-matched NDB may not be essential for discriminating patients with AD from normal participants using 18 F-FDG PET.