Depression and all-cause and coronary heart disease mortality among adults with and without diabetes
Depression and all-cause and coronary heart disease mortality among adults with and without diabetes
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DOI：
10.2337/diacare.28.6.1339
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发表时间：
2005-06-01
期刊：
影响因子：
16.2
通讯作者：
Zheng, D
中科院分区：
文献类型：
--
作者：
Egede, LE;Nietert, PJ;Zheng, D
目的-本研究的目的是评估抑郁症对有糖尿病和无糖尿病的成年人的全因和冠心病（CHD）死亡率的影响。025名参与者参加了基于人口的国家健康和营养检查调查I流行病学随访-研究对象是1982年还活着并接受采访的人，他们有流行病学研究中心抑郁量表的完整数据。基于1982年的糖尿病和抑郁状态创建了四个组：1）无糖尿病，无抑郁（参考组）; 2）无糖尿病，存在抑郁; 3）存在糖尿病，无抑郁;和14）存在糖尿病，存在抑郁。考克斯比例风险回归模型被用来计算多变量调整的危险比（HR）的死亡为每个组相比，参考group.RESULTS -超过8年（83,624人年的后续行动），1,925人死亡的记录，包括522例死于冠心病。每1,000人年随访的死亡率在糖尿病和抑郁症患者中最高。与对照组相比，全因死亡率的HR为无糖尿病，存在抑郁，1.20（95% CI 1.03-1.40）;存在糖尿病，无抑郁，1.88（1.55-2.27）;存在糖尿病，存在抑郁，2.50（2.04-3.08）。冠心病死亡率的危险比为无糖尿病、存在抑郁症、1.29（0.96-1.74）;存在糖尿病，无抑郁2.26（1.60-3.21）;有糖尿病和抑郁症的人，2.43（1.66-3.56）。结论-糖尿病和抑郁症的共存与各种原因死亡的风险显着增加有关，除此之外，由于糖尿病或抑郁症。
OBJECTIVE - The aim of this study was to evaluate the effect of depression on all-cause and coronary heart disease (CHD) mortality among adults with and without diabetes.RESEARCH DESIGN AND METHODS - We studied 10,025 participants in the population-based National Health and Nutrition Examination Survey I Epidentiologic Follow-up Study who were alive and interviewed in 1982 and had complete data for the Center for Epidemiologic Studies Depression Scale. Four groups were created based on diabetes and depression status in 1982: 1) no diabetes, no depression (reference group); 2) no diabetes, depression present; 3) diabetes present, no depression; and i4) diabetes present, depression present. Cox proportional hazards regression models were used to calculate multivariate-adjusted hazard ratios (HRs) of death for each group compared with the reference group.RESULTS - Over 8 years (83,624 person-years of follow-up), 1,925 deaths were documented, including 522 deaths from CHD. Mortality rate per 1,000 person-years of follow-up was highest in the group with both diabetes and depression. Compared with the reference group, HRs for all-cause mortality were no diabetes, depression present, 1.20 (95% CI 1.03-1.40); diabetes present, no depression 1.88 (1.55-2.27); and diabetes present, depression present, 2 50 (2.04-3.08). HRs for CHD mortality were no diabetes, depression present, 1.29 (0.96-1.74); diabetes present, no depression 2.26 (1.60-3.21); and diabetes present, depression present, 2.43 (1.66-3.56).CONCLUSIONS - The coexistence of diabetes and depression is associated with a significantly increased risk of death from all causes, beyond that due to having either diabetes or depression alone.