Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.
Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.
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具有超高弛豫率的聚多巴胺涂层氧化锰纳米颗粒作为磁共振成像引导协同化疗/光热治疗的纳米治疗剂
DOI：
10.1039/c6sc01320a
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发表时间：
2016-11-01
期刊：
影响因子：
8.4
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Ding X;Liu J;Li J;Wang F;Wang Y;Song S;Zhang H
构建了一种多功能的核/壳纳米热疗平台，可用于肿瘤的MRI引导下的联合化疗和光热治疗。锰基纳米粒子被认为是一类新的磁共振成像探针，但其低弛豫度一直是阻碍其在体内应用的主要因素。在此，我们设计并构建了一种多功能纳米热疗材料(FA-Mn3O4@PDA@PEG)，用于MRI引导的肿瘤联合化疗/光热治疗(PTT)。14.47 mm~(-1)S~(-1)的超高弛豫度使其成为一种良好的体内外磁共振造影剂，为肿瘤诊断提供了全面的信息。与单纯PTT或化疗相比，FA-Mn3O4@PDA@PEG在808 nm近红外激光照射下表现出显著的协同治疗效果，治疗效率高，药物副作用低。这些发现很有意义，并将激励我们开发高效的MRI引导下的协同化疗/光热治疗癌症治疗。
A multifunctional core/shell nanotheranostic platform was constructed which could offer MRI guided combinational chemotherapy and photothermal therapy for cancer. Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications in vivo. Herein, we designed and constructed a multifunctional nanotheranostic (FA-Mn3O4@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM–1 s–1 makes the nanotheranostic an excellent contrast agent for MRI in vitro and in vivo, and provides comprehensive information for tumor diagnosis. When irradiated with an 808 nm NIR laser, FA-Mn3O4@PDA@PEG exhibits a remarkably improved and synergistic therapeutic effect compared to PTT or chemotherapy alone, providing high therapeutic efficiency and low side effects of drugs. These findings are of great interest and will inspire us to develop highly effective MRI guided synergetic chemo-/photothermal therapy for cancer treatment.