Cell migration capability of vascular endothelial growth factor into the root apex of a root canal model in vivo.
Cell migration capability of vascular endothelial growth factor into the root apex of a root canal model in vivo.
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DOI：
10.2334/josnusd.17-0456
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发表时间：
2018-12
影响因子：
1.9
通讯作者：
T. Matsuura;K. Sugimoto;Viviane K S Kawata-Matsuura;K. Yanagiguchi;Shizuka Yamada;Y. Hayashi
中科院分区：
文献类型：
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作者：
T. Matsuura;K. Sugimoto;Viviane K S Kawata-Matsuura;K. Yanagiguchi;Shizuka Yamada;Y. Hayashi
一旦牙齿发生深龋，牙髓组织受到不可逆的感染，应将受感染的牙髓组织清除，并在根管中放置填充材料。根管治疗的牙齿容易发生牙根折或根尖周炎;然而，牙髓组织具有预防牙根折或根尖周炎的潜力。因此，牙髓切除术后的牙髓再生可能有助于延长牙齿寿命。本研究开发了一种新的牙髓再生方法。将吸附有血管内皮生长因子的胶原凝胶注射到制备的根管模型的根管内，置于大鼠背部，并培养3周。取出植入物后，进行组织学分析。结果发现，大鼠体细胞被招募到根管移植模型的根尖。这些发现为牙髓组织工程提供了一种新的潜在技术。
Once a tooth develops deep caries and the dental pulp tissue is irreversibly infected, the infected dental pulp tissue should be removed, and filling material should be placed in the root canal. Endodontically treated teeth are prone to root fracture or periapical periodontitis; however, dental pulp tissue has the potential to prevent root fracture or periapical periodontitis. Therefore, dental pulp regeneration after pulpectomy may help prolong tooth life. In this study, a new method of dental pulp regeneration was developed. Vascular endothelial growth factor-adsorbed collagen gel was injected into the root canal of a prepared root canal model, placed into the dorsum of a rat, and cultured for 3 weeks. After retrieving the implant, histological analysis was performed. It was found that rat somatic cells were recruited into the root apex of the transplanted root canal model. These findings suggest a new potential technique for engineering dental pulp tissue.