Our ancestry dictates clonal architecture and skin cancer susceptibility.
Our ancestry dictates clonal architecture and skin cancer susceptibility.
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我们的祖先决定了克隆结构和皮肤癌的易感性。
DOI：
10.1038/s41588-023-01467-y
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发表时间：
2023
期刊：
影响因子：
30.8
通讯作者：
DeGregori,James
中科院分区：
文献类型：
--
作者：
DeDominici,Marco;DeGregori,James
角化细胞皮肤癌的发病率在世界不同地区的人群之间有显著差异。对来自英国和新加坡的个体的正常皮肤中的体细胞突变的详细分析揭示了可能导致差异风险的克隆突变景观的不同模式。
Incidence of keratinocyte skin cancer varies markedly between populations living in different areas of the world. A detailed analysis of somatic mutations in the normal skin of individuals from the UK and Singapore reveals different patterns of clonal mutational landscapes that could contribute to differential risk.