Reduced pulmonary function is associated with lower levels of endogenous total and free testosterone. The Tromso Study
Reduced pulmonary function is associated with lower levels of endogenous total and free testosterone. The Tromso Study
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DOI：
10.1007/s10654-006-9095-9
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发表时间：
2007-02-01
影响因子：
13.6
通讯作者：
Aasebo, Ulf
中科院分区：
文献类型：
--
作者：
Svartberg, Johan;Schirmer, Henrik;Aasebo, Ulf
患有慢性阻塞性肺病的男性内源性睾酮水平降低。然而，在普通人群中，关于肺功能和内源性睾酮水平之间的关系知之甚少。在目前的研究中，我们对参与第五项特罗姆索研究的2197名男性进行了免疫测定法测量的性激素与肺活量测定仪和血氧饱和度评估的肺功能之间的横断面相关性研究。数据分析采用单因素相关分析、多元线性回归分析、方差和协方差分析。总睾酮和游离睾酮与用力肺活量、用力肺活量(占预计值的百分比)(P=0.001和P=0.006)、1秒用力呼气量、用力呼气量(占预计值的百分比)呈正相关(P=0.033和P=0.002)，重度肺梗阻(占预计值的FEV1%)患者的游离睾酮水平较低(P=0.005)。在来自特罗姆索的这一横断面数据中，肺功能的下降与总睾酮和游离睾酮水平的降低有关。我们认为，总睾酮和游离睾酮的减少可能是由于下丘脑-垂体反应的改变。
Men with chronic obstructive pulmonary disease have reduced endogenous testosterone levels. Little is known, however, about the relationship between pulmonary function and endogenous testosterone levels in a general population. In the present study we have examined the cross-sectional associations between sex hormones measured by immunoassay and pulmonary function assessed with spirometry and oxygen saturation in 2,197 men participating in the fifth Tromso study. The data were analyzed by univariate correlations, multiple linear regression analyses and analyses of variance and covariance. Total and free testosterone were positively and independently associated with forced vitality capacity, FVC (% of predicted) (P = 0.001 and P = 0.006, respectively) and forced expiratory volume in 1 second, FEV1 (% predicted) ( P = 0.033 and P = 0.002, respectively), and men with severe pulmonary obstruction ( FEV1 % of predicted < 50) had lower free testosterone levels ( P = 0.005). In this cross-sectional data from Tromso, a reduction in pulmonary function was associated with lower levels of total and free testosterone. We suggest that the reduction of total and free testosterone could be due to an alteration of the hypothalamic-pituitary response.