Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy
Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy
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DOI：
10.1212/01.wnl.0000316120.70504.d5
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发表时间：
2008-09-09
期刊：
影响因子：
9.9
通讯作者：
Savic, I.
中科院分区：
文献类型：
--
作者：
Ciumas, C.;Wahlin, T. -B. Robins;Savic, I.
背景：青少年肌阵挛性癫痫（JME）常出现行为和认知问题。其潜在机制尚不清楚。基于先前的数据显示多巴胺系统参与运动和认知功能，我们测试了JME是否可能与该系统的变化有关，以及这些变化是否与这些患者的发作间期功能障碍有关。方法：应用PET和[（11）C] PE 2I研究12例JME患者和12例健康对照者的多巴胺转运体（DAT）的局部结合潜力。计算中脑、黑质、尾状核和壳核中的结合电位。我们还测试了在几个神经心理学测试中各自的措施和性能之间可能存在的相关性。结果如下：患者黑质和中脑的结合电位降低（p = 0.009和0.007），尾状核和壳核的结合电位正常。他们还表现出精神速度和运动功能受损，在一些测试中，这与中脑的DAT结合潜力有关。结论：多巴胺信号似乎在多巴胺能神经元的靶区域（纹状体和额叶）受损，并与JME中的几种发作间期功能障碍有关。这些发现为JME的病理生理学增添了一个新的方面。
Background: Behavioral and cognitive problems are frequently encountered in juvenile myoclonic epilepsy (JME). The underlying mechanisms are unknown. Based on previous data showing that the dopamine system is involved in motor as well as cognitive functions, we tested whether JME may be associated with changes in this system, and if such changes are linked to interictal dysfunctions in these patients. Method: PET and [(11)C] PE2I was used to investigate the regional binding potential to the dopamine transporter (DAT) in 12 patients with JME and 12 healthy controls. Binding potential was calculated in the midbrain, substantia nigra, caudate, and putamen. We also tested possible correlations between the respective measures and performance in several neuropsychological tests. Results: Patients had a reduced binding potential in the substantia nigra and midbrain (p = 0.009 and 0.007), and normal values in the caudate and putamen. They also exhibited impaired psychomotor speed and motor function, which in some tests correlated with DAT binding potential in the midbrain. Conclusion: Dopamine signaling seems impaired in the target regions for dopaminergic neurons (the striatum and frontal lobe), and related to several interictal dysfunctions in JME. The findings add a new aspect to the pathophysiology of JME.