Influence of thrombin-induced disseminated intravascular coagulation on the arteriolar mechanics in the rat mesentery.
Influence of thrombin-induced disseminated intravascular coagulation on the arteriolar mechanics in the rat mesentery.
复制标题
凝血酶诱导的弥散性血管内凝血对大鼠肠系膜小动脉力学的影响。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Y. Goto
中科院分区：
文献类型：
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作者：
T. Kato;Y. Goto
本文分析了实验性弥散性血管内凝血（DIC）的微循环障碍。在凝血酶输注前15分钟静脉注射氨甲环酸（100 mg/kg）抑制纤维蛋白溶解，并在随后的60分钟内输注凝血酶（200 IU/体）。停止凝血酶输注后，剖腹观察肠系膜微循环。通过与电视监视器结合的图像分裂方法测量小动脉的内径（20-30微米）。早期出现淤渣、瘀点等微循环障碍，微动脉直径逐渐增大。对儿茶酚胺的缩血管反应呈剂量依赖性增强。实验数据表明，危险的微循环障碍可能会发生由于过度治疗DIC使用儿茶酚胺。
Microcirculatory disturbances in experimental disseminated intravascular coagulation (DIC) were analyzed. Fibrinolysis was inhibited by the intravenous injection of tranexamic acid (100 mg/kg) 15 minutes before thrombin infusion, and thrombin (200 IU/body) was infused for the following 60 minutes. After stopping the thrombin infusion, laparotomy was performed for the observation of the microcirculation in the mesentery. The internal diameter of arterioles (20-30 microns) was measured by the image-splitting method incorporated with a television monitor. The microcirculatory disturbances such as sludge and petechia appeared in the early period, and the arteriolar diameter increased gradually. The vasoconstrictive response to catecholamines was enhanced dose dependently. Experimental data suggest that dangerous disorders in the microcirculation might occur as a result of excessive treatment of DIC using catecholamines.