Therapy Monitoring with Functional and Molecular MR Imaging
Therapy Monitoring with Functional and Molecular MR Imaging
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DOI：
10.1016/j.mric.2015.08.003
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发表时间：
2016-02-01
影响因子：
1.6
通讯作者：
Baleato-Gonzalez, Sandra
中科院分区：
文献类型：
--
作者：
Garcia-Figueiras, Roberto;Padhani, Anwar R.;Baleato-Gonzalez, Sandra
癌症治疗主要基于手术、放疗和化疗的不同组合。此外，靶向治疗（旨在破坏特定的肿瘤标志，如血管生成，代谢，增殖，侵袭性和免疫逃避），肿瘤治疗，免疫治疗和介入技术已经成为替代肿瘤治疗。传统的成像技术和当前的反应标准并不总是提供关于治疗成功的必要信息，特别是对于靶向治疗。在这种情况下，磁共振成像提供了一个有吸引力的解剖，生理和分子信息的组合，这可能会超越这些限制，并越来越多地用于治疗反应评估。
Cancer therapy is mainly based on different combinations of surgery, radiotherapy, and chemotherapy. Additionally, targeted therapies (designed to disrupt specific tumor hallmarks, such as angiogenesis, metabolism, proliferation, invasiveness, and immune evasion), hormonotherapy, immunotherapy, and interventional techniques have emerged as alternative oncologic treatments. Conventional imaging techniques and current response criteria do not always provide the necessary information regarding therapy success particularly to targeted therapies. In this setting, MR imaging offers an attractive combination of anatomic, physiologic, and molecular information, which may surpass these limitations, and is being increasingly used for therapy response assessment.