False positive and false negative FDG-PET scans in various thoracic diseases.
False positive and false negative FDG-PET scans in various thoracic diseases.
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DOI：
10.3348/kjr.2006.7.1.57
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发表时间：
2006-01
影响因子：
4.8
通讯作者：
Im JG
中科院分区：
文献类型：
--
作者：
Chang JM;Lee HJ;Goo JM;Lee HY;Lee JJ;Chung JK;Im JG
氟脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）越来越多地用于区分良性和恶性局灶性病变，它已被证明比传统的胸部计算机断层扫描（CT）更有效。然而，FDG不是癌症特异性试剂，并且已报道了良性疾病中的假阳性结果。感染性疾病（分枝杆菌、真菌、细菌感染）、结节病、放射性肺炎和术后手术条件在PET扫描上显示出强烈的摄取。另一方面，具有低糖酵解活性的肿瘤如腺瘤、细支气管肺泡癌、类癌、低级别淋巴瘤和小尺寸肿瘤在PET扫描上显示假阴性结果。此外，在位于生理摄取部位（心脏、膀胱、肾脏和肝脏）附近的疾病中，FDG-PET应与其他成像方式互补，以确认结果并最大限度地减少假阴性结果。熟悉这些假阳性和假阴性结果将有助于放射科医生更准确地解释PET扫描，也有助于确定结果的重要性。在这篇综述中，我们说明了假阳性和阴性结果的PET扫描在各种疾病。
Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. Infectious diseases (mycobacterial, fungal, bacterial infection), sarcoidosis, radiation pneumonitis and post-operative surgical conditions have shown intense uptake on PET scan. On the other hand, tumors with low glycolytic activity such as adenomas, bronchioloalveolar carcinomas, carcinoid tumors, low grade lymphomas and small sized tumors have revealed false negative findings on PET scan. Furthermore, in diseases located near the physiologic uptake sites (heart, bladder, kidney, and liver), FDG-PET should be complemented with other imaging modalities to confirm results and to minimize false negative findings. Familiarity with these false positive and negative findings will help radiologists interpret PET scans more accurately and also will help to determine the significance of the findings. In this review, we illustrate false positive and negative findings of PET scan in a variety of diseases.