Hepatitis C virus: the growing challenge
Hepatitis C virus: the growing challenge
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DOI：
10.1093/bmb/ldp003
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发表时间：
2009-03-01
影响因子：
6.7
通讯作者：
Thomson, Brian J.
中科院分区：
文献类型：
--
作者：
Thomson, Brian J.
丙型肝炎病毒（HCV）是世界范围内肝脏疾病的主要原因。在工业化国家，静脉注射吸毒者是主要的感染源。在发展中国家，关于HCV的信息相对较少。同行评审的出版物和主要学术会议上的演讲。HCV相关的肝硬化和肝细胞癌死亡可能在未来三十年急剧上升。紧急干预是必要的，以尽量减少疾病的负担，在那些已经感染，并减少新的感染，特别是在IDU population.Current模式的护理和委托在英国和其他国家不充分识别或治疗注射吸毒者的HCV感染的发病率。大多数策略侧重于疾病预防，而不是针对新的感染。目前正在开发和验证新的护理模式。HCV复制新模式的开发将改变我们对HCV感染的理解和治疗能力。
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. In industrialized countries, intravenous drug users (IDUs) are the main reservoir of infection. Relatively little information is available on HCV in the developing world.Peer reviewed publications and presentations at major academic meetings.HCV-related cirrhosis and death from hepatocellular carcinoma are likely to rise dramatically in the next three decades. Urgent intervention is required both to minimize the burden of disease in those already infected and to reduce the incidence of new infections, particularly in the IDU population.Current models of care and commissioning in the UK and other countries do not adequately identify or treat HCV infection in IDUs. Most strategies focus on disease prevention and do not target new infections.New models of care are currently being developed and validated.The development of new models of HCV replication will transform our understanding and capacity to treat HCV infection.