CHARACTERIZATION OF PROTON NMR RELAXATION TIMES IN NORMAL AND PATHOLOGICAL TISSUES BY CORRELATION WITH OTHER TISSUE PARAMETERS
CHARACTERIZATION OF PROTON NMR RELAXATION TIMES IN NORMAL AND PATHOLOGICAL TISSUES BY CORRELATION WITH OTHER TISSUE PARAMETERS
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DOI：
10.1016/0730-725x(84)90063-8
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
FULLERTON G D
中科院分区：
文献类型：
--
作者：
CAMERON I L;ORD V A;FULLERTON G D
为了帮助理解哪些组织参数最好地解释水质子NMR弛豫时间，在10.7MHz和29 ° C下测量来自正常成年大鼠的16个组织的纵向弛豫时间（T1）、横向弛豫时间（T2）和水含量。C.对上述参数和其他组织参数进行回归分析。这些其他组织参数包括以下内容：各种有机和无机成分的量，蛋白质合成速率，O2消耗速率和形态组成。此外，还研究了正常肝脏和恶性肿瘤（Morris#7777，一种可移植性肝癌）之间T1、T2和水含量值的差异，以帮助理解如何通过NMR光谱检测和表征疾病状态。本研究的结果和来自文献的信息允许对组织T1和T2值进行以下概括：每个正常组织具有相当一致和特征的T1和T2弛豫时间，其总是短于本体水的T1和T2;组织T2值与含水量的相关性不如T1值，T1值较短的组织具有较高的计算水化分数、较多的粗面内质网和较高的蛋白质合成活性速率;与细胞内非膜结合脂滴相关的具有较高脂质含量的组织倾向于具有较长的T2值;具有更大总表面积的组织，无论是细胞膜或细胞内或细胞外纤维状大分子的形式，倾向于具有较短的T2值;肿瘤和正常组织之间的T1和T2值之间的差异与细胞外液体积的体积分数（量）以及细胞中的膜和纤维状表面积的量的差异相关。上述概括在预测与特定组织病理相关的T1和T2变化时应该是有用的。
To help understand which tissue parameters best account for the water proton NMR relaxation times, the longitudinal relaxation time (T1), the transverse relaxation time (T2) and the water content of 16 tissues from normal adult rats were measured at 10.7 MHz and 29.degree. C. Regression analyses between the above and other tissue parameters were performed. These other tissue parameters included the following: the amounts of various organic and inorganic components, protein synthetic rate, O2 consumption rate and morphological composition. In addition, the differences in T1, T2 and water content values between normal liver and malignant tumor (Morris #7777 a transplantable hepatoma) were studied to help understand how a disease state can be detected and characterized by NMR spectroscopy. The results of this study and information from the literature allow the following generalizations to be made about tissue T1 and T2 values: each normal tissue has rather consistent and characteristic T1 and T2 relaxation times which are always shorter than the T1 and T2 of bulk water; tissues with higher water content tend to have longer T1 relaxation times; tissue T2 values are not as well correlated with water content as T1 values; tissues with shorter T1 values have higher calculated hydration fractions, greater amounts of rough endoplasmic reticulum and a greater rate of protein synthetic activity; tissues with higher lipid content, associated with intracellular non-membrane bounded lipid droplets, tend to have longer T2 values; tissues with greater overall surface area, whether in the form of cellular membranes or intracellular or extracellular fibrillar macromolecules, tend to have shorter T2 values; the differences between T1 and T2 values between tumor and normal tissues correlated with differences in the volume fraction (amounts) of extracellular fluid volumes and in the amounts of membrane and fibrillar surface area in the cells. The above generalizations should be useful in predicting T1 and T2 changes associated with specific tissue pathologies.