Fish nasal immunity: From mucosal vaccines to neuroimmunology
Fish nasal immunity: From mucosal vaccines to neuroimmunology
复制标题
DOI：
10.1016/j.fsi.2020.05.076
复制
发表时间：
2020-09-01
影响因子：
4.7
通讯作者：
Salinas, Irene
中科院分区：
文献类型：
--
作者：
Das, Pankoj Kumar;Salinas, Irene
与陆生脊椎动物一样，硬骨鱼也有一个鼻咽相关淋巴组织（NALT），可以保护宿主免受入侵病原体的侵害。尽管鼻免疫在鱼类免疫学中是一个相对较新的领域，但对鼻免疫系统的研究已经阐明了硬骨鱼粘膜免疫系统和神经免疫学的基本方面。在这篇综述中，我们强调了鼻部感染在硬骨鱼中的重要性，以及在了解鱼类如何局部和全身性地对鼻部感染或疫苗接种做出反应方面所取得的进展。我们还想强调在免疫反应过程中嗅觉器官中神经元和免疫细胞之间的复杂相互作用。我们预测，类似的神经免疫相互作用在硬骨鱼的所有粘膜组织的免疫反应。因此，了解硬骨鱼NALT中粘膜免疫应答的原理揭示了鱼类粘膜免疫的重要方面，这些方面对于水产养殖中的粘膜接种至关重要。
Like terrestrial vertebrates, bony fishes have a nasopharynx-associated lymphoid tissue (NALT) that protects the host against invading pathogens. Despite nasal immunity being a relatively new field in fish immunology, the investigation of nasal immune systems has already illuminated fundamental aspects of teleost mucosal immune systems as well as neuroimmunology. In this review, we highlight the importance of nasal infections in bony fish and the progress that has been made towards understanding how fish respond locally and systemically to nasal infection or vaccination. We also want to highlight the complex interactions between neurons and immune cells that occur in the olfactory organ during the course of an immune response. We predict that similar neuroimmune interactions govern immune responses at all mucosal tissues in bony fish. Understanding the principles of mucosal immune responses in teleost NALT has therefore revealed important aspects of fish mucosal immunity that are critical for mucosal vaccination in aquaculture.