Nitric oxide in heart failure: friend or foe.
Nitric oxide in heart failure: friend or foe.
复制标题
DOI：
10.1023/a:1020767731450
复制
发表时间：
2002-10-01
影响因子：
4.6
通讯作者：
Jugdutt, Bodh I
中科院分区：
文献类型：
--
作者：
Jugdutt, Bodh I
一氧化氮 (NO) 是一种有争议的分子。它要么是有益的，要么是有害的。与 NO 供体一样，这种二元性的原因之一与剂量有关。小剂量就非常有益，可以维持血管中的血流和血压，并防止外来入侵者。高剂量时，它会导致低血压，形成具有细胞毒性的过氧亚硝酸盐，并导致心力衰竭。
Nitric oxide (NO) is a controversial molecule. It is either beneficial or deleterious. As with NO donors, one reason for this duality is related to the dose. Small doses are highly beneficial, maintaining blood flow in vessels and blood pressure, and protecting against foreign invaders. In high doses, it results in hypotension, forms peroxynitrite which is cytotoxic, and contributes to heart failure.