Herbal Supplement Use and Blood Lead Levels of United States Adults
Herbal Supplement Use and Blood Lead Levels of United States Adults
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DOI：
10.1007/s11606-009-1050-5
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发表时间：
2009-11-01
影响因子：
5.7
通讯作者：
Mittleman, Murray A.
中科院分区：
文献类型：
--
作者：
Buettner, Catherine;Mukamal, Kenneth J.;Mittleman, Murray A.
一些草药补充剂可能含有铅。为了检查在过去30天内使用特定草药膳食补充剂是否与美国男性和女性的血铅水平相关。横断面分析。NHANES参与者从1999-2004年，平民非制度化美国人口的代表性样本。血液中的铅被测量。铅和自我报告的补充剂使用之间的关联是使用多变量回归加权来估计的，以解释NHANES采样。调查的草药补充剂是以前报道的含有高重金属含量的补充剂：阿育吠陀或传统中药草药，紫锥菊，银杏，人参，圣约翰草，和其他草药（具体来说，卡瓦，缬草，黑升麻，蜂花粉和荨麻）。在6,712名妇女中，每千日元20年，使用草药补充剂的人的铅水平比不使用者高10%（95%CI 3%-17%，p = 0.005）。使用阿育吠陀或传统中药草药、圣约翰草和“其他”草药的妇女的铅水平分别比不使用者高24%（95% CI 5%-45%，p = 0.01）、23%（95% CI 4%-46%），p = 0.02）和21%（95% CI 2%-44%，p = 0.03）。没有观察到草药使用与男性铅水平之间存在显著关联（n = 6，095）。在育龄妇女（16-45岁）中，草药补充剂使用者的铅水平比非使用者高20%（95% CI 5%-34%，p = 0.008）。与此相反，大蒜和其他膳食补充剂与较高的铅水平无关。使用特定的草药补充剂与女性血铅水平较高有关。我们的数据表明，需要对草药补充剂和限制补充剂中铅的法规进行测试。
Some herbal supplements may contain lead.To examine whether use of specific herbal dietary supplements during the last 30 days is associated with blood lead levels in US men and women.Cross-sectional analysis.NHANES participants from 1999-2004, a representative sample of the civilian non-institutionalized US population.Lead was measured in blood. Associations between lead and self-reported supplement use were estimated using multivariable regression weighted to account for NHANES sampling. Herbal supplements investigated were those previously reported to contain high heavy metal content: Ayurvedic or traditional Chinese medicine herbs, echinacea, ginkgo, ginseng, St. John's wort, and "other" herbs (specifically, kava, valerian, black cohosh, bee pollen, and nettle).Among 6,712 women a parts per thousand yen20 years, those using herbal supplements had lead levels that were 10% higher than non-users (95% CI 3%-17%, p = 0.005). Women using Ayurvedic or traditional Chinese medicine herbs, St. John's wort, and "other" herbs had lead levels 24% (95% CI 5%-45%, p = 0.01), 23% (95% CI 4%-46%), p = 0.02), and 21% (95% CI 2%-44%, p = 0.03) higher, respectively, than non-users. No significant associations were observed between herb use and lead levels among men (n = 6,095). Among reproductive-aged women (16-45 years), herbal supplement users had lead levels 20% higher than non-users (95% CI 5%-34%, p = 0.008). In contrast, garlic and other dietary supplements were not associated with higher lead levels.Use of specific herbal supplements is associated with higher blood lead levels among women. Our data suggest testing guidelines for herbal supplements and regulations limiting lead in supplements are needed.