Of microbes and men
Of microbes and men
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DOI：
10.1111/j.1600-0668.2005.00344.x
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发表时间：
2005-01-01
期刊：
影响因子：
5.8
通讯作者：
Seuri, M
中科院分区：
文献类型：
--
作者：
Nevalainen, A;Seuri, M
建筑结构中的湿气积累、水损害地点的微生物生态以及人类接触生物污染物是复杂的现象，可能导致各种类型的室内空气污染和不利的健康后果。通常报告的是与建筑物有关的刺激症状、呼吸道感染和非特异性症状，偶尔还有神经损伤。各种疾病与霉菌暴露有关，例如哮喘发展和恶化的风险增加以及过敏性肺炎、婴儿肺出血和风湿性疾病的集群。这些疾病的致病因素仍然知之甚少，可能与细菌和真菌与环境生长基质和其他微生物之间的复杂相互作用有关，这导致了各种各样的接触。生长在建筑材料上的真菌和细菌可能产生有毒的次级代谢产物，而建筑材料似乎是代谢产物产生的关键决定因素。现代建筑技术为微生物提供了新的生态位，它们很容易利用水分控制的缺陷。为了更好地描述建筑物中的微生物暴露，目前的方法开发侧重于生物量的化学标记和特定基因序列的测定。
Moisture accumulation in building structures, the microbial ecology of water-damaged sites and human exposure to biological contaminants are complex phenomena and may result in various types of indoor air pollution and adverse health outcomes. Commonly reported are building-related irritation symptoms, respiratory infections and non-specific symptoms and occasionally neurological impairment. Various diseases have been associated with mold exposure, e.g. an increased risk of asthma development and exacerbation as well as clusters of hypersensitivity pneumonitis, pulmonary hemorrhage in infants and rheumatic diseases. The causal agents of these illnesses, still poorly understood, may be linked to the complex interactions between bacteria and fungi with environmental growth substrates and other microorganisms which lead to a wide diversity of exposures. Fungi and bacteria growing on building materials may produce toxic secondary metabolites, and the material appears to be a key determinant of metabolite production. Modern building technology has provided new ecological niches for microbes which readily exploit faults in moisture control. To better describe microbial exposures in buildings, current method development focuses on chemical markers of biomass and assays for specific genetic sequences.