Maghemite based silicone composite for arterial embolization hyperthermia.
Maghemite based silicone composite for arterial embolization hyperthermia.
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DOI：
10.1016/j.msec.2014.12.046
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
I. Smolkova;N. Kazantseva;Kira N. Makoveckaya;P. Smolka;P. Sáha;A. M. Granov
中科院分区：
文献类型：
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作者：
I. Smolkova;N. Kazantseva;Kira N. Makoveckaya;P. Smolka;P. Sáha;A. M. Granov
研制了一种用于动脉栓塞热疗的纳米级镁铁矿有机硅复合材料。它具有栓塞性、交变磁场加热效率高、不透射线等特点。选择复合材料的初始成分，使材料保持液体20分钟，为肿瘤血管系统的经导管运输和填充提供机会。诱导期过后，黏度迅速增加，形成软性栓子，可阻断肿瘤血管。该复合材料的热稳定性高达225°C，具有橡胶弹性性质，热膨胀系数高于血液。由于Neel磁化松弛，均匀分布在复合材料中的磁铁矿纳米颗粒提供了其快速加热(数十°C/分钟−/1)。通过添加碘化钾，可获得所需的X射线对比度。
Maghemite nanoparticle based silicone composite for application in arterial embolization hyperthermia is developed. It possesses embolization ability, high heating efficiency in alternating magnetic fields and radiopaque property. The initial components of the composite are selected so that the material stays liquid for 20 min, providing the opportunity for transcatheter transportation and filling of the tumour vascular system. After this induction period the viscosity increases rapidly and soft embolus is formed which is able to occlude the tumour blood vessels. The composite is thermally stable up to 225 °C, displays rubber-elastic properties and has a thermal expansion coefficient higher than that of blood. Maghemite nanoparticles uniformly distributed in the composite provide its rapid heating (tens of °C min− 1) due to Neel magnetization relaxation. Required X-ray contrast of composite is achieved by addition of potassium iodide.