Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development
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DOI：
10.1016/s1567-133x(03)00114-5
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发表时间：
2003-10-01
影响因子：
1.2
通讯作者：
Gessler, M
中科院分区：
文献类型：
--
作者：
Leimeister, C;Schumacher, N;Gessler, M
相邻细胞通过Notch信号传导的相互作用导致高度组织化组织的细胞命运决定、分化和图案化。具有来自Notch信号转导途径的基因的靶向破坏的小鼠在发育中的体节、神经原性结构、血管、心脏和其他器官中显示出缺陷。最近的研究增加了在肾脏、胰腺和胸腺形态发生期间对Notch信号传导的要求。在这里，我们描述了所有四种受体（Notch 1-4），五种跨膜配体（Dill，3，4，Jag 1和Jag 2），细胞内效应子（Hey基因）和细胞外调节子（Lfng，Mfng，Rfng）在发育中的小鼠后肾中的表达。我们的研究结果指出，Lfng依赖的作用Notch信号在肾单位段的发展，特别是近端小管。(C)2003 Elsevier B. V.保留所有权利。
The interaction of neighboring cells via Notch signalling leads to cell fate determination, differentiation and patterning of highly organized tissues. Mice with targeted disruption of genes from the Notch signal transduction pathway display defects in the developing somites, neurogenic structures, blood vessels, heart and other organs. Recent studies have added requirements for Notch signalling during kidney, pancreas and thymus morphogenesis. Here, we describe the expression of all four receptors (Notch 1-4), the five transmembrane ligands (Dill, 3, 4, Jag 1 and Jag2), intracellular effectors (the Hey genes) and extracellular modulators (Lfng, Mfng, Rfng) in the developing mouse metanephros. Our results point to a Lfng-dependent role for Notch signalling in the development of nephron segments, especially the proximal tubules. (C) 2003 Elsevier B.V. All rights reserved.