Use of cell morphology as early bioindicator for viral infection
Use of cell morphology as early bioindicator for viral infection
复制标题
使用细胞形态作为病毒感染的早期生物指示剂
DOI：
10.1049/iet-nbt.2013.0032
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发表时间：
2014-03-01
影响因子：
2.3
通讯作者：
Zhao，Xin
中科院分区：
文献类型：
--
作者：
Ding，Xianting;Liu，Ningxia;Zhao，Xin
本研究报告了细胞形态与适应水泡性口炎病毒感染的能力之间的相关性。采用时间推移方法跟踪同源细胞在适应病毒感染方面的个体差异。作者的单细胞分析表明，在病毒感染后，纺锤形的成熟细胞在感染24小时后不太可能被感染。另一方面，处于圆形的正在增殖的细胞倾向于在相同的时间内接受更高的病毒感染。这一事实表明，细胞形态可能是病毒感染的早期生物指标。这项研究的结果可能适用于其他病毒感染模型。
This study reports a correlation between cellular morphology and the ability of adapting to vesicular stomatitis virus infection. A time‐lapse approach was employed to track the individual difference between homologous cells in adapting to viral infection. The authors single‐cell analysis indicates that upon viral infection, mature cells that are in spindle shape are less likely to be infected after 24 h infection. On the other hand, cells undergoing proliferation, which are in rounder shape, tend to adopt a much higher viral infection within the same amount of time. This fact suggests that cellular morphology may be an early bioindicator for viral infection. The findings in this study could potentially be applied to other viral infection models.