Long-term potentiation (LTP) of human sensory-evoked potentials
Long-term potentiation (LTP) of human sensory-evoked potentials
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DOI：
10.1002/wcs.62
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发表时间：
2010-09-01
影响因子：
3.9
通讯作者：
Teyler, Timothy J.
中科院分区：
文献类型：
--
作者：
Kirk, Ian J.;McNair, Nicolas A.;Teyler, Timothy J.
长时程增强（LTP）是学习记忆的主要突触机制，已在实验动物的细胞和分子水平上得到了广泛的研究。由于缺乏人类模型，对LTP功能意义的研究一直受到阻碍，直到最近，LTP仅在从接受手术的患者中获得的分离的皮质组织中直接证明，在那里它显示出与非人类制剂中所见相同的性质。在这篇简短的综述中，我们描述了我们实验室最近开发的用于诱导LTP样视觉和神经诱发电位变化的范例的结果。我们描述了如何快速，重复呈现的感觉刺激导致持续增强的组件的感觉诱发电位在正常人。迄今为止的实验，调查这些LTP样变化的位点，刺激特异性和NMDA受体依赖性表明，它们具有在实验动物中观察到的LTP的基本特征。从非手术患者引出LTP的能力将提供一个人类模型系统，允许在正常受试者中详细检查突触可塑性，并可能在认知障碍的评估中具有未来的临床应用。(C)2010 John Wiley & Sons，Ltd.
Long-term potentiation (LTP) is the principal candidate synaptic mechanism underlying learning and memory, and has been studied extensively at the cellular and molecular level in laboratory animals. Inquiry into the functional significance of LTP has been hindered by the absence of a human model as, until recently, LTP has only been directly demonstrated in humans in isolated cortical tissue obtained from patients undergoing surgery, where it displays properties identical to those seen in non-human preparations. In this brief review, we describe the results of paradigms recently developed in our laboratory for inducing LTP-like changes in visual-, and auditory-evoked potentials. We describe how rapid, repetitive presentation of sensory stimuli leads to a persistent enhancement of components of sensory-evoked potential in normal humans. Experiments to date, investigating the locus, stimulus specificity, and NMDA receptor dependence of these LTP-like changes suggest that they have the essential characteristics of LTP seen in experimental animals. The ability to elicit LTP from non-surgical patients will provide a human model system allowing the detailed examination of synaptic plasticity in normal subjects and may have future clinical applications in the assessment of cognitive disorders. (C) 2010 John Wiley & Sons, Ltd. WIREs Cogn Sci 2010 1 766-773