A systematic approach to the formulation of anti‐onychomycotic nail patches
A systematic approach to the formulation of anti‐onychomycotic nail patches
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DOI：
10.1016/j.ejpb.2018.02.032
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发表时间：
2018-03
影响因子：
4.9
通讯作者：
K. Rizi;I. K. Mohammed;K. Xu;A. Kinloch;M. Charalambides;S. Murdan
中科院分区：
文献类型：
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作者：
K. Rizi;I. K. Mohammed;K. Xu;A. Kinloch;M. Charalambides;S. Murdan
指甲贴片具有作为药物载体的潜在作用，用于局部治疗指甲疾病，例如甲真菌病（一种常见疾病）。因此，我们的目标是开发一种系统且新颖的方法来配制简单的药物粘性指甲贴剂。对十二种压敏粘合剂 (PSA)、四种背衬膜、两种防粘衬垫和三种药物的药物和机械性能进行了筛选。从初步筛选中，选择了两种 PSA、两种药物、一种背衬膜和一种防粘衬垫进行进一步研究。通过溶剂浇铸制备贴片并进行表征。贴剂具有良好的厚度和药物含量均匀性，并且在六个月的储存期间显示出最小的药物结晶。同时，贴剂在储存时的药物稳定性以及贴剂对指甲的粘附力受到药物、PSA和背衬膜性质的影响。所报告的方法为系统配制指甲贴片铺平了道路，以添加到指甲药物的武器库中。此外，从这项工作中，已经确定了最佳的贴剂配方。
Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. Our aim was therefore to develop a systematic and novel approach to the formulation of a simple drug-in-adhesive ungual patch. Twelve pressure-sensitive adhesives (PSAs), four backing membranes, two release liners and three drugs were screened for pharmaceutical and mechanical properties. From this initial screening, two PSAs, two drugs, one backing membrane and one release liner were selected for further investigation. Patches were prepared by solvent-casting and characterised. The patches had good uniformity of thickness and of drug content, and showed minimal drug crystallisation during six months of storage. Meanwhile, the drug stability in the patch upon storage and patch adhesion to the nail was influenced by the nature of the drug, the PSA and the backing membrane. The reported methodology paves the way for a systematic formulation of ungual nail patches to add to the armamentarium of nail medicines. Further, from this work, the best patch formulation has been identified.