Are Sleep Disturbances Preclinical Markers of Parkinson's Disease?
Are Sleep Disturbances Preclinical Markers of Parkinson's Disease?
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DOI：
10.1007/s11064-014-1488-7
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发表时间：
2015-03-01
影响因子：
4.4
通讯作者：
Barreto, George E.
中科院分区：
文献类型：
--
作者：
dos Santos, Altair B.;Kohlmeier, Kristi A.;Barreto, George E.
帕金森病（Parkinson's disease，PD）是一种以运动症状和体征以及嗅觉功能障碍、疼痛、睡眠障碍和认知障碍等非运动异常为特征的神经行为障碍。在这些改变中，睡眠障碍在病理学中起重要作用，但目前诊断中不考虑睡眠障碍的存在。然而，睡眠问题可能先于PD的经典运动异常多年，应在疾病发作前作为潜在标志物进行临床评估。第一个被报道的具有这种潜力的干扰是REM睡眠行为障碍，目前其他几种干扰作为潜在的标志物已经获得了重要性，例如过度的日间嗜睡，不宁腿综合征和新的证据也指出了昼夜节律的变化。在这里，我们提出了一个简短的审查的主要证据表明，睡眠障碍之前的运动症状在PD和神经退行性病变发生在可能导致这些现象的地区，以提供支持的结论，睡眠障碍应被视为有价值的临床前标志物PD。
Parkinson's disease (PD) is a neurobehavioral disorder characterized by motor symptoms and signs, and non-motor abnormalities such as olfactory dysfunction, pain, sleep disorders and cognitive impairment. Amongst these alterations, sleep disturbances play an important role in the pathology, but presence of disturbed sleep is not currently considered in diagnosis. However, sleeping problems may precede by many years the classic motor abnormalities of PD and should be clinically evaluated as a potential marker before disease onset. The first disturbance reported with this potential was the disorder REM sleep behaviour and currently several other disturbances have gained importance as potential markers, such as excessive daytime sleepiness, restless legs syndrome and new evidence also points to changes in circadian rhythms. Here we present a brief review of the major evidence indicating that sleep disturbances precede the motor symptoms in PD and neurodegeneration occurs in regions that could underlie these phenomena in order to provide support for the conclusion that disturbances of sleep should be considered as valuable preclinical markers for PD.