The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task
The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task
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DOI：
10.1016/s0893-133x(00)00111-1
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发表时间：
2000-09-01
影响因子：
7.6
通讯作者：
Arnsten, AFT
中科院分区：
文献类型：
--
作者：
Avery, RA;Franowicz, JS;Arnsten, AFT
研究表明，去甲肾上腺素通过作用于突触后α-2a肾上腺素受体，增强前额叶皮质(PFC)的工作记忆功能。目前的研究考察了α-2A型肾上腺素受体激动剂鸟苷法辛(0.7 mg/kg，肌肉注射)与生理盐水对进行空间工作记忆任务的猴子局部脑血流量(RCBF)SPECT测量的影响。在进行工作记忆任务的同时，动物通过静脉留置导管注入SPECT血流示踪剂Tcm-99mECD。金刚烷治疗显著改善了工作记忆任务的认知表现，并显著增加了背外侧PFC的rCBF值，这是大脑中与空间工作记忆任务表现最密切相关的区域。相比之下，金刚烷对上颞叶皮质的rCBF没有显著影响，这是一个与任务表现无关的听觉关联区。这些数据与刺激α-2A型肾上腺素能受体优先增强PFC功能的假设一致。(C)2000年美国神经精神药理学学院。爱思唯尔科学公司出版。保留所有权利。
Research indicates that norepinephrine enhances the working memory functions of the prefrontal cortex (PFC) through actions at post-synaptic, alpha-2A adrenoceptors. The current study examined the effects of the alpha-2A adrenoreceptor agonist, guanfacine (0.7 mg/kg, i.m.), compared to saline on SPECT measures of regional cerebral blood flow (rCBF) in monkeys performing a spatial working memory task. Animals were infused with the SPECT blood flow tracer, Tcm-99m ECD, through an indwelling intravenous catheter while performing the working memory task. Guanfacine treatment significantly improved cognitive performance of the working memory task, and significantly increased rCBF values in the dorsolateral PFC, the brain region most tightly associated with performance of spatial working memory tasks. In contrast, guanfacine had no significant effect on rCBF in the superior temporal cortex, an auditory association area unrelated to task performance. These data are consistent with the hypothesis that alpha-2A adrenoceptor stimulation preferentially enhances functioning of the PFC. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.