Pathways of retinol and retinoic acid metabolism in the rat.
Pathways of retinol and retinoic acid metabolism in the rat.
复制标题
大鼠视黄醇和视黄酸代谢途径。
作者：
A. Roberts;H. DeLuca
1.用~（14）C标记视黄酸和醋酸视黄酯，经静脉注射生理量的这些化合物到缺乏视黄醇的大鼠体内，研究了它们在不同部位的代谢。2.对尿液、二氧化碳和粪便中产生的放射性进行分析，得出这两种化合物代谢存在三种主要途径的假设。3.有证据表明，视黄酸和视黄醇的代谢是通过相同或至少相似的途径，视黄醇成为氧化的羧基状态之前发生的任何降解的类异戊二烯侧链。4.从这些数据中无法确定视黄酸是否是视黄醇途径中的中间体。5.调节视黄醇代谢的可能的网站进行了讨论。
1. The metabolism of retinoic acid and retinyl acetate labelled with (14)C in various positions was studied after intravenous injection of physiological amounts of these compounds into retinol-deficient rats. 2. Analysis of the resultant radio-activity in the urine, carbon dioxide and faeces led to a postulation of the existence of three major pathways for the metabolism of these two compounds. 3. Evidence is presented that retinoic acid and retinol are metabolized by either the same or at least similar pathways and that retinol becomes oxidized to the carboxyl state before any degradation of the isoprenoid side chain occurs. 4. It is not possible to decide from these data whether retinoic acid is an intermediate in the retinol pathway. 5. Possible sites for the regulation of retinol metabolism are discussed.