Sex differences in HIV-1 viral load and absolute CD4 cell count in long term survivors HIV-1 infected patients from Giurgiu, Romania
Sex differences in HIV-1 viral load and absolute CD4 cell count in long term survivors HIV-1 infected patients from Giurgiu, Romania
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DOI：
10.2478/rrlm-2013-0010
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发表时间：
2013-06-01
影响因子：
0.5
通讯作者：
Marinescu, Paul
中科院分区：
文献类型：
--
作者：
Manolescu, Loredana;Marinescu, Paul
简介：先前的研究评估了与成人和儿童中人类免疫缺陷病毒（HIV）RNA水平和绝对CD 4细胞计数相关的性别差异，接受或未接受抗逆转录病毒（ARV）治疗，结果相互矛盾。目的：评估来自一个大型HIV感染长期存活患者队列的男性和女性的HIV RNA水平和绝对CD 4细胞计数的比较。研究方法：对462例HIV感染者进行了横断面和纵向分析，分为三组：156例未经治疗的死亡患者，死亡时的中位年龄为10岁，197例ARV治疗患者，中位年龄为17岁，109例ARV治疗患者，中位年龄为23岁，随访至2011年。在入组研究的所有患者中测量HIV RNA和绝对CD 4细胞计数。结果如下：在对156名初次治疗患者进行的横断面分析中，女性HIV RNA中位水平低于男性，分别为4.95和5.73 HIV RNA log 10（拷贝/ml）。女性绝对CD 4细胞计数略高;（中位数97 vs. 65.5细胞/mu L; P=0.0001）。对197例接受抗逆转录病毒治疗的患者进行的横断面分析显示，女性的log 10 HIV RNA水平低于男性（P=0.0001），女性的中位CD 4计数值也较低，女性为336个细胞/μ L，男性为456个细胞/μ L，P= 0.0001。纵向分析显示统计学显着结果：女性的平均log病毒载量较低（F=13.90，P=0.0009），男性的CD 4细胞绝对计数较低（F=16.72，P
Introduction: Prior studies assessing sex differences correlated with the levels of human immunodeficiency virus (HIV) RNA and absolute CD4 cell count in adults and children, treated or untreated with antiretroviral (ARV) therapy presented conflicting results. Objective: To assess comparative HIV RNA levels and absolute CD4 cell count in men and women from a large cohort of HIV-infected long term survivors patients. Methods: 462 HIV infected patients were analyzed cross-sectionally and longitudinally after being split into three groups: 156 naive deceased patients, median age at death 10 years, 197 ARV treated patients, median age 17 years and 109 ARV treated patients, median age 23 years followed up until 2011. HIV RNA and absolute CD4 cell count were measured in all patients enrolled in the study. Results: In cross-sectional analysis of 156 naive patients HI V RNA median levels were lower in females comparing to males, 4.95 vs. 5.73 HIV RNA log10 (copies/ml). Female absolute CD4 cell count was slightly higher; (median 97 vs. 65.5 cells/mu L; P=0.0001). Cross-sectional analysis of 197 ARV treated patients showed a lower log10 HIV RNA level in females compared to males, (P=0.0001), and also lower median CD4 count values in women, 336 cells/mu L vs 456 cells/mu L in men, P=.0001. Longitudinal analysis revealed statistically significant results: mean log viral loads were lower in females (F=13.90, P=0.0009) and absolute CD4 cell count was lower in malse (F=16.72, P