Human milk whey glycoprotein N-glycans varied greatly among different maternal secretor status.
Human milk whey glycoprotein N-glycans varied greatly among different maternal secretor status.
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DOI：
10.1016/j.carbpol.2023.120728
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发表时间：
2023-06
影响因子：
11.2
通讯作者：
Xiaoqin Wang;Wenqing Li;Zhenhua Li;Tianjiao Han;Jinqiao Rong;Jiangbo Fan;Linjuan Huang;Yu Lu;Zhongfu Wang
中科院分区：
文献类型：
--
作者：
Xiaoqin Wang;Wenqing Li;Zhenhua Li;Tianjiao Han;Jinqiao Rong;Jiangbo Fan;Linjuan Huang;Yu Lu;Zhongfu Wang
Human milk glycans are complex carbohydrates, which play a pivotal role in infant health and neonatal development. Maternal secretor status is known to affect free oligosaccharides in milk. Here, the milkN-glycome of secretor (Se+) and nonsecretor (Se−) individuals was qualitatively and quantitatively analyzed by hydrophilic interaction chromatography-electrospray ionization-tandem mass spectrometry. The total glycosylation, fucosylation, and sialylation ofN-glycans was three times higher in the Se+ group compared to the Se− group (p< 0.001) per equal volume of milk. Importantly, 52 out of 63N-glycans—including the eight most abundant ones—differed greatly between Se+ and Se− individuals (p< 0.05). Moreover, nineN-glycans (H5N3F1, H6N3, H3N5F1, H5N5F1, H5N5F1S1, H5N4F3S1, H6N4F2S1, H6N5F4S1, and H8N7S1) were >10 times more abundant in Se+ milk than in Se− milk. These findings lay a glycomics-basis for designing personalized nutrition supplements for infants.
