Initial neurogenesis in Drosophila
Initial neurogenesis in Drosophila
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DOI：
10.1002/wdev.111
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发表时间：
2013-09-01
影响因子：
--
通讯作者：
Wodarz, Andreas
中科院分区：
文献类型：
--
作者：
Hartenstein, Volker;Wodarz, Andreas
早期神经发生包括神经系统发育的阶段，在此期间神经祖细胞诞生。在早期发育中，胚胎外胚层被保守的信号传导机制细分为两个主要结构域，表皮外胚层和神经外胚层。随后，神经外胚层的细胞被内化并形成增殖神经祖细胞的细胞层。在脊椎动物中，整个神经外胚层折叠成胚胎，产生神经管。在果蝇和许多其他无脊椎动物中，神经外胚层细胞的一个子集，称为神经母细胞（NB），在胚胎内分层并形成神经原基，在那里它们以不对称的干细胞样模式分裂。留在表面的神经外胚层细胞的其余部分失去了它们的神经原性潜能，随后产生表皮的腹侧部分。遗传和分子分析的机制控制规范和增殖的果蝇胚胎，发挥了重要的一部分，在开拓现代发育神经生物学领域，代表了本次审查的主题。(c)2013 Wiley Periodicals，Inc.
Early neurogenesis comprises the phase of nervous system development during which neural progenitor cells are born. In early development, the embryonic ectoderm is subdivided by a conserved signaling mechanism into two main domains, the epidermal ectoderm and the neurectoderm. Subsequently, cells of the neurectoderm are internalized and form a cell layer of proliferating neural progenitors. In vertebrates, the entire neurectoderm folds into the embryo to give rise to the neural tube. In Drosophila and many other invertebrates, a subset of neurectodermal cells, called neuroblasts (NBs), delaminates and forms the neural primordium inside the embryo where they divide in an asymmetric, stem cell-like mode. The remainder of the neurectodermal cells that stay behind at the surface loose their neurogenic potential and later give rise to the ventral part of the epidermis. The genetic and molecular analysis of the mechanisms controlling specification and proliferation of NBs in the Drosophila embryo, which played a significant part in pioneering the field of modern developmental neurobiology, represents the topic of this review. (c) 2013 Wiley Periodicals, Inc.