Optical tomography-measured retinal nerve fiber layer thickness in normal Latinos
Optical tomography-measured retinal nerve fiber layer thickness in normal Latinos
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DOI：
10.1167/iovs.02-0975
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发表时间：
2003-08-01
影响因子：
4.4
通讯作者：
Lai, M
中科院分区：
文献类型：
--
作者：
Varma, R;Bazzaz, S;Lai, M
目的。采用光学相干断层扫描（OCT）测量正常拉丁美洲人视网膜神经纤维层（RNFL）厚度。312名年龄在40岁或以上的拉丁裔参与者接受了详细的眼科检查，包括测量视力、眼压、视野验光和立体视盘摄影。没有参与者有任何高眼压、青光眼或其他眼部疾病的证据。通过光学相干断层扫描（OCT模型2000；Carl Zeiss Meditec, Dublin， CA，软件版本a6.1）对每位参与者的一只眼睛进行了9次扫描：3次乳头周围扫描和6次黄斑径向扫描。测量乳头周围区和黄斑区RNFL的平均厚度。采用配对t检验和线性回归分析对数据进行分析。参与者的平均年龄为52岁（范围40-79岁）。乳突周围RNFL平均厚度为1.74 mm，距椎间盘中心132.7 +/- 14.4 mm，黄斑RNFL平均厚度为44.8 +/- 14.8 mm。黄斑视网膜平均厚度为173 +/- 28.5 mm。四个象限的平均乳头周围RNFL厚度为：上象限157.7 +/- 17.8，鼻象限109.3 +/- 19.1，下象限159.8 +/- 18.9，颞象限102.5 +/- 19.0。黄斑和乳头周围RNFL厚度无性别差异（P = 0.12和P = 0.35）。老年拉丁美洲人黄斑和乳头周围RNFL的平均厚度比年轻拉丁美洲人薄（P = 0.04和P = 0.0001）。在诊断和监测患有影响RNFL的疾病的个体时，应考虑乳头周围和黄斑RNFL厚度的区域和年龄相关差异。
PURPOSE. To measure retinal nerve fiber layer (RNFL) thickness in normal Latinos using optical coherence tomography (OCT).METHODS. Three hundred twelve Latino participants, aged 40 years or more, underwent a detailed ophthalmic examination, including measurement of visual acuity, intraocular pressure, visual field perimetry, and stereoscopic optic disc photography. None of the participants had any evidence of ocular hypertension, glaucoma, or other ocular disease. Nine scans were performed on one eye of each participant by optical coherence tomography (OCT Model 2000; Carl Zeiss Meditec, Dublin, CA, software version A 6.1): three circumferential peripapillary scans and six radial scans of the macula. The average RNFL thicknesses in the peripapillary region and macula were measured. A paired t-test and linear regression analyses were used to analyze the data.RESULTS. The mean age of the participants was 52 years (range, 40-79 years). The average peripapillary RNFL thickness 1.74 Dun from the center of the disc was 132.7 +/- 14.4 mum, and the average macular RNFL thickness was 44.8 +/- 14.8 mum. The average macular retinal thickness was 173 +/- 28.5 mum. The average peripapillary RNFL thickness in the four quadrants was as follows: superior 157.7 +/- 17.8 mum, nasal 109.3 +/- 19.1 mum, inferior 159.8 +/- 18.9 mum, and temporal 102.5 +/- 19.0 mum. There were no gender-related differences in macular or peripapillary RNFL thickness (P = 0.12 and P = 0.35, respectively). The average macular and peripapillary RNFL thickness was thinner in older Latinos than in younger Latinos (P = 0.04 and P = 0.0001, respectively).CONCLUSIONS. Regional and age-related differences in the peripapillary and macular RNFL thickness should be considered when diagnosing and monitoring individuals with diseases that affect the RNFL.