Comparison of catechin profiles in human plasma and urine after single dosing and regular intake of green tea (Camellia sinensis)
Comparison of catechin profiles in human plasma and urine after single dosing and regular intake of green tea (Camellia sinensis)
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DOI：
10.1017/s0007114512004370
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发表时间：
2013-06-28
影响因子：
3.6
通讯作者：
Benzie, Iris F. F.
中科院分区：
文献类型：
--
作者：
Fung, Shing-Tack;Ho, Cyrus K.;Benzie, Iris F. F.
单次给药和定期摄入绿色茶后血浆和尿液中的绿色茶（茶树）儿茶素谱尚不清楚。我们对16名健康志愿者进行了一项安慰剂对照干预研究，以确定单剂量和每日两次绿色茶1周后总儿茶素和游离儿茶素的变化。在饮用200 ml 1.5%（w/v）绿色茶或水（每组8例）之前（空腹）和之后（60和120 min血液; 90和180 min尿液）采集血液和尿液样本，并在每天两次150 ml 1%（w/v）补充绿色茶或水7 d后再次采集空腹样本。在4周洗脱期后，受试者被交叉到其他治疗组，并重复程序。在摄入后1小时的血浆结果显示升高的（P EGC > ECG，并且急性血浆反应反映了这一点。然而，在慢性消耗后，在空腹血浆中几乎没有发现EGC，存在一些EGCG，但保持相当高的ECG水平。
Green tea (Camellia sinensis) catechin profiles in plasma and urine following single dosing and regular ingestion of green tea are not clear. We performed a placebo-controlled intervention study with sixteen healthy volunteers to determine changes in total and free catechins after a single dose and following 1 week of twice-daily green tea. Blood and urine samples were collected before (fasting) and after (60 and 120 min for blood; 90 and 180 min for urine) drinking 200 ml of 1.5% (w/v) green tea or water (n 8 each), and fasting samples were again collected after 7 d of 150 ml of 1% (w/v) supplemental green tea or water twice daily. After a 4-week washout, subjects were crossed onto the other treatment and procedures repeated. Plasma results at 1 h post-ingestion showed elevated (P EGC > ECG, and the acute plasma response mirrored this. However, after chronic consumption there was almost no EGC found in fasting plasma, some EGCG was present, but a rather high level of ECG was maintained.