Parametric Functional Maps of Visual Inputs to the Tectum
Parametric Functional Maps of Visual Inputs to the Tectum
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DOI：
10.1016/j.neuron.2012.08.040
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发表时间：
2012-10-18
期刊：
影响因子：
16.2
通讯作者：
Meyer, Martin P.
中科院分区：
文献类型：
--
作者：
Nikolaou, Nikolas;Lowe, Andrew S.;Meyer, Martin P.
视觉场景的特征是如何在视网膜神经节细胞（RGC）的群体活动中编码的，这些细胞靶向大脑的特定区域，目前还没有很好的理解。为了解决这个问题，我们使用了一个遗传编码的报告突触前功能（SyGCaMP3）记录视觉诱发活动的RGC轴突支配的斑马鱼顶盖人口。使用无偏的SyGCaMP3信号的体素分析，我们确定了三个亚型的方向选择性和两个亚型的方向选择性视网膜输入。在许多幼虫中产生的复合参数功能图显示了方向和方向选择性反应的分层分离，以及功能亚型分布中意想不到的retinotopic偏差。这些研究结果提供了一个系统的描述的形式，组织和视觉输入到大脑的维度，并将作为一个平台，了解与视觉驱动的行为相关的顶盖电路的新兴属性。
How features of the visual scene are encoded in the population activity of retinal ganglion cells (RGCs) targeting specific regions of the brain is not well understood. To address this, we have used a genetically encoded reporter of presynaptic function (SyGCaMP3) to record visually evoked activity in the population of RGC axons innervating the zebrafish tectum. Using unbiased voxel-wise analysis of SyGCaMP3 signals, we identify three subtypes of direction-selective and two subtypes of orientation-selective retinal input. Composite parametric functional maps generated across many larvae show laminar segregation of direction- and orientation-selective responses and unexpected retinotopic biases in the distribution of functional subtypes. These findings provide a systematic description of the form, organization, and dimensionality of visual inputs to the brain and will serve as a platform for understanding emergent properties in tectal circuits associated with visually driven behavior.