Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age
Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age
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DOI：
10.1111/j.1600-0714.2004.00291.x
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发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Speight, PM
中科院分区：
文献类型：
--
作者：
Sasaki, T;Moles, DR;Speight, PM
背景：文献中关于年轻口腔鳞状细胞癌（SCC）患者的临床病程存在相当大的争议。本研究的目的是评估口腔鳞状细胞癌的临床病理特征之间的年轻people.METHODS：从一个队列的529例患者诊断为鳞状细胞癌，35（6.6%）的年龄在40岁以下。该组进行了比较，以确定是否有任何差异，在两组之间的临床病理特征的对照组110例年龄在40岁以上。最常见的部位是舌（51.3%），其次是口底、颊粘膜、上下牙槽和牙龈。局部和区域控制率为64.8%，这是类似的老年患者在此series.CONCLUSIONS：口腔鳞癌的预后在年轻患者并没有出现从老年人口的不同。单因素分析显示，临床分期和侵袭方式是影响年轻和老年患者预后的最重要因素。
BACKGROUND: Considerable controversy exists in the literature regarding the clinical course of young patients with oral squamous cell carcinoma (SCC). The purpose of this study was to evaluate the clinico-pathological features of oral SCC among young people.METHODS: From a cohort of 529 patients diagnosed with SCC, 35 (6.6%) were under the age of 40 years. This group was compared to a control group of 110 cases aged over 40 to determine if there were any differences in clinicopathological features between the two groups.RESULTS: In the young group there were 20 males and 15 females. The site was most frequently the tongue (51.3%), followed by the floor of the mouth, the buccal mucosa, and the upper and lower alveolus and gingiva. The local and regional control rate was 64.8% which was similar to that of older patients in this series.CONCLUSIONS: The prognosis of oral SCC in the young patients does not appear to be different from that of the older population. Univariate analysis showed that clinical stage and the mode of invasion were the most significant prognostic factors in both younger and older patients.