HIV-1 Assembly, Budding, and Maturation
HIV-1 Assembly, Budding, and Maturation
复制标题
DOI：
10.1101/cshperspect.a006924
复制
发表时间：
2012-07-01
影响因子：
5.4
通讯作者：
Kraeusslich, Hans-Georg
中科院分区：
文献类型：
--
作者：
Sundquist, Wesley I.;Kraeusslich, Hans-Georg
逆转录病毒的一个决定性特性是它们能够组装成颗粒，这些颗粒可以离开生产细胞并将感染传播到易感细胞和宿主。病毒体形态发生可分为三个阶段：组装，其中产生病毒体并包装必需组分;出芽，其中病毒体穿过质膜并获得其脂质包膜;和成熟，其中病毒体改变结构并变得具有感染性。所有这些阶段都由Gag多聚蛋白及其蛋白水解成熟产物协调，其作为病毒的主要结构蛋白发挥作用。在这里，我们回顾我们目前的理解HIV-1的组装，出芽和成熟的机制，从一个总体概述，然后提供病毒形态发生的每个不同阶段的详细描述。
A defining property of retroviruses is their ability to assemble into particles that can leave producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis can be divided into three stages: assembly, wherein the virion is created and essential components are packaged; budding, wherein the virion crosses the plasma membrane and obtains its lipid envelope; and maturation, wherein the virion changes structure and becomes infectious. All of these stages are coordinated by the Gag polyprotein and its proteolytic maturation products, which function as the major structural proteins of the virus. Here, we review our current understanding of the mechanisms of HIV-1 assembly, budding, and maturation, starting with a general overview and then providing detailed descriptions of each of the different stages of virion morphogenesis.