The Ovotransferrin-Derived Peptide IRW Attenuates Lipopolysaccharide-Induced Inflammatory Responses
The Ovotransferrin-Derived Peptide IRW Attenuates Lipopolysaccharide-Induced Inflammatory Responses
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DOI：
10.1155/2019/8676410
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发表时间：
2019-01-01
影响因子：
--
通讯作者：
Zhang, Peng
中科院分区：
文献类型：
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作者：
Jiao, Huanli;Zhang, Qing;Zhang, Peng
IRW（Ile-Arg-Trp）是一种从卵转铁蛋白中提取的生物活性肽，具有抗炎作用。在这项研究中，IRW对炎症细胞因子和微生物群的影响，探讨在人脐静脉内皮细胞（HUVECs）和脂多糖（LPS）诱导的大鼠炎症性腹膜炎模型。腹腔注射LPS建立大鼠腹膜炎模型。在引入LPS之前，HUVEC暴露于IRW 12小时。值得注意的是，IRW对LPS诱导的腹膜炎具有有益作用，特别是通过降低血清肿瘤坏死因子（TNF）和白细胞介素（IL）-6水平以及髓过氧化物酶（MPO）活性（P
IRW (Ile-Arg-Trp), a bioactive peptide isolated from egg ovotransferrin, has been shown to exert anti-inflammatory effects. In this study, the effects of IRW on inflammatory cytokines and microbiota were explored in human umbilical vein endothelial cells (HUVECs) and a lipopolysaccharide (LPS)-induced rat model of inflammatory peritonitis. Rats were injected intraperitoneally with LPS to establish peritonitis. HUVECs were exposed to IRW for 12h before introducing LPS. Notably, IRW exerted beneficial effects against LPS-induced peritonitis, specifically, by reducing the serum levels of tumour necrosis factor (TNF)- and interleukin (IL)-6 and myeloperoxidase (MPO) activity (P