DOPA REACTION TEST IN HAIR BULBS OF FETUSES AND ITS APPLICATION TO THE PRENATAL-DIAGNOSIS OF ALBINISM
DOPA REACTION TEST IN HAIR BULBS OF FETUSES AND ITS APPLICATION TO THE PRENATAL-DIAGNOSIS OF ALBINISM
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DOI：
10.1016/0190-9622(91)70030-6
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发表时间：
1991-02-01
影响因子：
13.8
通讯作者：
GILHAR, A
中科院分区：
文献类型：
--
作者：
GERSHONIBARUCH, R;BENDERLY, A;GILHAR, A
没有关于胎儿中正常存在的酪氨酸酶量的信息。 从流产后获得的正常胎儿头皮的毛球中进行的多巴反应试验表明，早在17周的胎儿中就存在酪氨酸酶。 在头皮以外的皮肤标本中只检测到微弱的活性。 该方法可作为酪氨酸酶阴性白化病产前诊断的一种快速、可靠的方法。
No information is available on the amount of tyrosinase normally present in fetuses. A dopa reaction test in hair bulbs from the scalp of normal fetuses obtained after abortion showed that tyrosinase is present in fetuses as early as 17 weeks. Only faint activity was detected in skin specimens other than from the scalp. This assay can serve as a quick and reliable method for the prenatal diagnosis of tyrosinase-negative albinism.