An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism
An investigation of the health effects caused by exposure to arsenic from drinking water and coal combustion: arsenic exposure and metabolism
复制标题
饮用水和煤炭燃烧中砷暴露对健康影响的调查：砷暴露和代谢
DOI：
10.1007/s11356-017-0203-z
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发表时间：
2017-11-01
影响因子：
5.8
通讯作者：
Wu, Kegong
中科院分区：
文献类型：
--
作者：
Wei, Binggan;Yu, Jiangping;Wu, Kegong
很少有研究进行比较砷暴露，代谢和甲基化的人群暴露于砷的饮用水和燃煤。为此，对陕西省某农村燃煤砷暴露人群（CCA）和内蒙古某农村饮水砷暴露人群（DWA）的环境砷浓度和尿砷形态进行了研究。CCA饮用水、室内空气和土壤中砷的平均浓度分别为4.52 μg/L、0.03 mg/m3和14.93 mg/kg。结果表明，饮水砷含量为144.71 μg/L，室内空气砷含量低于检测限，土壤砷含量为10.19 mg/kg。DWA和CCA的砷日总摄入量分别为4.47和3.13 μg/d·kg。DWA中有皮肤病变的受试者的平均尿无机砷（iAs）、单甲基胂酸（MMA）、二甲基胂酸（DMA）和总砷（TA）浓度分别为50.41、47.01、202.66和300.08 μg/L。无皮肤病变受试者的浓度分别为49.76、44.20、195.60和289.56 μg/L。来自CCA的受试者尿液中TA中的%iAs、%MMA和%DMA分别为12.24、14.73和73.03%，而来自DWA的相应值分别为17.54、15.57和66.89%。DWA中的受试者通常具有比CCA中的受试者更高的%iAs和%MMA，以及更低的%DMA，以及初级和二级甲基化指数（PMI和SMI）。结果表明，长期暴露于高浓度砷环境中，对DWA和CCA中砷甲基化效率有显著影响。DWA中较低的PMI和SMI值表明，由于饮用水中砷的摄入，砷甲基化能力较低。然而，目前尚不清楚两组之间砷代谢的差异是否是由于暴露水平或暴露途径的差异。
Few studies have been conducted to compare arsenic exposure, metabolism, and methylation in populations exposed to arsenic in drinking water and from coal combustion. Therefore, arsenic concentrations in the environment and arsenic speciation in the urine of subjects exposed to arsenic as a consequence of coal combustion in a rural area in Shaanxi province (CCA) and in drinking water in a rural area in Inner Mongolia (DWA) were investigated. The mean arsenic concentrations in drinking water, indoor air, and soil in CCA were 4.52 μg/L, 0.03 mg/m3, and 14.93 mg/kg, respectively. The mean arsenic concentrations in drinking water and soil in DWA were 144.71 μg/L and 10.19 mg/kg, respectively, while the level in indoor air was lower than the limit of detection. The total daily intakes of arsenic in DWA and CCA were 4.47 and 3.13 μg/day·kg, respectively. The mean urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsenic acid (DMA), and total arsenic (TAs) for subjects with skin lesions in DWA were 50.41, 47.01, 202.66, and 300.08 μg/L. The concentrations for subjects without skin lesions were 49.76, 44.20, 195.60, and 289.56 μg/L, respectively. The %iAs, %MMA, and %DMA in the TAs in the urine of subjects from CCA were 12.24, 14.73, and 73.03%, while the corresponding values from DWA were 17.54, 15.57, and 66.89%, respectively. The subjects in DWA typically had a higher %iAs and %MMA, and a lower %DMA, and primary and secondary methylation index (PMI and SMI) than the subjects in CCA. It was concluded that the arsenic methylation efficiency of subjects in DWA and CCA was significantly influenced by chronic exposure to high levels of arsenic in the environment. The lower PMI and SMI values in DWA revealed lower arsenic methylation capacity due to ingestion of arsenic in drinking water. However, it remained unclear if the differences in arsenic metabolism between the two groups were due to differences in exposure levels or in exposure route.