Mechanisms of noise-induced hearing loss indicate multiple methods of prevention
Mechanisms of noise-induced hearing loss indicate multiple methods of prevention
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DOI：
10.1016/j.heares.2006.10.006
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发表时间：
2007-04-01
期刊：
影响因子：
2.8
通讯作者：
Miller, Josef M.
中科院分区：
文献类型：
--
作者：
Le Prell, Colleen G.;Yamashita, Daisuke;Miller, Josef M.
最近的研究表明，耳蜗血流量减少和自由基形成在噪声性听力损失 (NIHL) 中发挥着重要作用。自由基形成的数量、分布和时程已被确定，包括噪声暴露后 7-10 天的具有临床意义的晚期形成，并且最终确定了噪声引起的耳蜗血流减少的一种机制。这些新的见解导致了关于 NIHL 分子机制的新假设的形成；由此，我们确定了预防 NIHL 的干预措施，即使治疗开始时间延迟至噪音后 3 天。现在有必要评估干预细胞死亡途径不同点的药物的累加效应，以优化治疗效果。找到减轻 NIHL 的安全有效的干预措施将为消除这一导致获得性听力损失的单一主要原因的人体试验提供令人信服的科学依据。 (C) 2006 Elsevier B.V. 保留所有权利。
Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss. (C) 2006 Elsevier B.V. All rights reserved.