Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence.
Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence.
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DOI：
10.3389/fmolb.2022.836417
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发表时间：
2022
影响因子：
5
通讯作者：
Almansour NM
中科院分区：
文献类型：
--
作者：
Almansour NM
三阴性乳腺癌 (TNBC) 是一种缺乏雌激素、孕激素和人类表皮生长因子受体 2 的乳腺癌。这种癌症占所有乳腺癌的 15-20% 以上，并且因其对治疗的低反应性和高侵袭性而在治疗上具有挑战性，因此受到特别的研究兴趣。由于缺乏针对 TNBC 的特定治疗方案，通常采用常规疗法进行治疗，但这往往会导致复发。本综述的重点是提供与 TNBC 流行病学、危险因素、转移、不同信号通路和可阻断的通路、TNBC 微环境的免疫抑制细胞、当前和研究疗法、预后以及人工智能在 TNBC 诊断中的作用相关的最新信息。本文提供的数据可能有助于该领域的研究人员获得一般和特定信息，以增进对 TNBC 的理解并在未来提供适当的疾病管理。
Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen, progesterone, and human epidermal growth factor receptor 2. This cancer is responsible for more than 15–20% of all breast cancers and is of particular research interest as it is therapeutically challenging mainly because of its low response to therapeutics and highly invasive nature. The non-availability of specific treatment options for TNBC is usually managed by conventional therapy, which often leads to relapse. The focus of this review is to provide up-to-date information related to TNBC epidemiology, risk factors, metastasis, different signaling pathways, and the pathways that can be blocked, immune suppressive cells of the TNBC microenvironment, current and investigation therapies, prognosis, and the role of artificial intelligence in TNBC diagnosis. The data presented in this paper may be helpful for researchers working in the field to obtain general and particular information to advance the understanding of TNBC and provide suitable disease management in the future.
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