Heritability of background EEG across the power spectrum
Heritability of background EEG across the power spectrum
复制标题
DOI：
10.1111/j.1469-8986.2005.00352.x
复制
发表时间：
2005-11-01
期刊：
影响因子：
3.7
通讯作者：
De Geus, EJC
中科院分区：
文献类型：
--
作者：
Smit, DJA;Posthuma, D;De Geus, EJC
我们估计了平均年龄为 26.2 岁和 49.4 岁的两个年龄组中遗传和非遗传（环境）对背景脑电图功率谱个体差异的贡献。对 142 名同卵双胞胎和 167 名异卵双胞胎及其兄弟姐妹（总共 760 名受试者）进行闭眼记录 19 导联脑电图。我们获得了 24 个 1 Hz 频段的功率谱，范围从 1.0 到 25.0 Hz。一般来说;遗传力在 α 峰值频率附近最高，在 θ 和 δ 频段较低。在测试版中，带遗传力随着频率的增加而逐渐降低，特别是在颞区。经典宽带功率之间的遗传相关性表明，一半到四分之三的遗传方差可以归因于共同的来源。我们的结论是，在头皮和大部分频谱上，成人脑电图的个体差异很大程度上是由遗传因素决定的。
We estimated the genetic and nongenetic (environmental) contributions to individual differences in the background EEG power spectrum in two age cohorts with mean ages of 26.2 and 49.4 years. Nineteen-lead EEG was recorded with eyes closed from 142 monozygotic and 167 dizygotic twin pairs and their siblings, totaling 760 subjects. We obtained power spectra in 24 bins of 1 Hz ranging from 1.0 to 25.0 Hz. Generally; heritability was highest around the alpha peak frequency and lower in the theta and delta bands. In the beta, band heritability gradually decreased with increasing frequency, especially in the temporal regions. Genetic correlations between power in the classical broad bands indicated that half to three-quarters of the genetic variance can be attributed to a common source. We conclude that across the scalp and most of the frequency spectrum, individual differences in adult EEG are largely determined by genetic factors.