The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse.
The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse.
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甲硝唑和米索硝唑 (Ro-07-0582) 对无胸腺突变裸鼠体内生长的人类恶性黑色素瘤的放射增敏作用。
DOI：
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发表时间：
1978
影响因子：
2.6
通讯作者：
T. Brustad
中科院分区：
文献类型：
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作者：
E. Rofstad;T. Brustad
两种亲电子硝基咪唑，甲硝唑和米索咪唑（Ro-07-0582）的放射增敏作用已在无胸腺突变裸鼠皮下生长的人恶性黑色素瘤上进行了测试。用~（60）Co治疗机对小鼠进行局部照射。在暴露于1250 rad前45 min，腹腔注射甲硝唑750 mg/kg和米索硝唑500 mg/kg。将肿瘤重新生长到其原始大小所需的时间与用1250，1875和2500 rad无药物治疗的肿瘤进行比较。甲硝唑和米索硝唑的增强比分别为1.2-1.3和1.4-1.5。结论：米索硝唑是一种比甲硝唑更有效的乏氧细胞放射增敏剂。前者可能被证明是人类放射治疗的价值。
The radiosensitizing effect of two electron-affinic nitroimidazoles, metronidazole and misonidazole (Ro-07-0582), has been tested on a human malignant melanoma grown subcutaneously in the athymic mutant nude mouse. A 60Co therapy unit was used for local irradiation of the mice. Metronidazole in doses of 750 mg/kg and misonidazole in doses of 500 mg/kg were administered intraperitoneally to the animals 45 min before exposure to 1250 rad. The time necessary for the tumours to regrow to their original sizes was compared with that of tumours treated with 1250, 1875 and 2500 rad without drug. The enhancement ratios were found to be 1.2-1.3 and 1.4-1.5 for metronidazole and misonidazole respectively. It is concluded that misonidazole is a more efficient hypoxic cell radiosensitizer for this human malignant melanoma than metronidazole. The former may prove to be of value in human radiotherapy.