Gastric cancer risk in relation to Helicobacter pylori infection and subtypes of intestinal metaplasia.
Gastric cancer risk in relation to Helicobacter pylori infection and subtypes of intestinal metaplasia.
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DOI：
10.1038/bjc.1998.453
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发表时间：
1998-07
影响因子：
8.8
通讯作者：
Lin, J T
中科院分区：
文献类型：
--
作者：
Wu, M S;Shun, C T;Lee, W C;Chen, C J;Wang, H P;Lee, W J;Lin, J T
幽门螺杆菌（H.幽门螺杆菌）感染和肠上皮化生（IM）均与胃癌（GC）风险增加相关。进一步探讨H. pylori和IM对GC、H. pylori和IM亚型在135个性别和年龄匹配的病例和对照组中进行了评估。采用多元Logistic回归分析计算每个危险因素发生GC的比值比（OR）和95%置信区间。H的OR。pylori感染与IM的相关系数分别为2.43（1.29-4.65）和4.59（2.58-8.16），I型IM的相关系数为0.82（0.28-2.36），II型IM的相关系数为2.03（0.95-4.34），III型IM的相关系数为39.75（14.34-110.2）。根据组织学亚型和胃癌分期的分层分析显示，肠型（12.8，4.73-34.83）和早期胃癌（6.40，2.25-18.18）中IM的OR特别高。我们的数据表明，H。pylori和IM与胃癌风险相关。III型IM是癌前病变的更特异性标志物，特别与早期和肠型GC相关。
Helicobacter pylori (H. pylori) infection and intestinal metaplasia (IM) are each associated with an increased risk of gastric cancer (GC). To explore further the influences of H. pylori and IM on GC, H. pylori and subtypes of IM were evaluated in 135 sex and age-matched case and control pairs. Odds ratios (ORs) with 95% confidence intervals of developing GC were calculated for each risk factor using multiple logistic regression analysis. ORs for H. pylori infection and IM were 2.43 (1.29-4.65) and 4.59 (2.58-8.16), respectively, and those for different IM subtypes gave values of 0.82 (0.28-2.36) for type I, 2.03 (0.95-4.34) for type II and 39.75 (14.34-110.2) for type III. Stratification analysis by histological subtype and stage of GC showed a particularly high OR for IM in intestinal type (12.8, 4.73-34.83) and early GC (6.40, 2.25-18.18). Our data indicate that both H. pylori and IM are related to GC risk. Type III IM is a more specific marker of premalignancy, with relevance, in particular, to the early and intestinal type of GC.