Genetic characterization of human immunodeficiency virus type 1 in elite controllers: Lack of gross genetic defects or common amino acid changes
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: Lack of gross genetic defects or common amino acid changes
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DOI：
10.1128/jvi.00535-08
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发表时间：
2008-09-01
影响因子：
5.4
通讯作者：
Walker, Bruce D.
中科院分区：
文献类型：
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作者：
Miura, Toshiyuki;Brockman, Mark A.;Walker, Bruce D.
尽管有报告称，在没有抗病毒治疗的情况下，控制人类免疫缺陷病毒I型（HIV-1）的人存在病毒遗传缺陷，但这种缺陷在多大程度上有助于长期控制病毒血症尚不清楚。大多数先前检测这类缺陷的研究只涉及少数受试者，主要集中在表达HLA-B57的受试者上，或者只检测了单个病毒基因，并且他们主要关注细胞前病毒DNA而不是血浆病毒RNA序列。在这里，我们试图对95名HIV-1精英控制者（EC）进行病毒测序，这些控制者的血浆病毒载量为
Despite reports of viral genetic defects in persons who control human immunodeficiency virus type I (HIV-1) in the absence of antiviral therapy, the extent to which such defects contribute to the long-term containment of viremia is not known. Most previous studies examining for such defects have involved small numbers of subjects, primarily focused on subjects expressing HLA-B57, or have examined single viral genes, and they have focused on cellular proviral DNA rather than plasma viral RNA sequences. Here, we attempted viral sequencing from 95 HIV-1 elite controllers (EC) who maintained plasma viral loads of