Temporal pattern in consumption of the first drink of the day in alcohol-dependent persons
Temporal pattern in consumption of the first drink of the day in alcohol-dependent persons
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DOI：
10.1081/cbi-120025533
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发表时间：
2003-01-01
影响因子：
2.8
通讯作者：
Touitou, Y
中科院分区：
文献类型：
--
作者：
Danel, T;Jeanson, R;Touitou, Y
对饮酒失去控制和对酒精的渴望是酒精依赖的主要标志。我们的临床实践表明，这些渴望不会在白天随机发生，而是在同一个病人每天的同一时间发生。为了验证这一假设，即酒精依赖患者对一天中第一杯酒的渴望具有昼夜节律性，我们要求217名根据DSM-IV标准诊断为酒精依赖的人完成一份调查问卷，调查这种渴望是否发生在每天的固定时间。在受访者中，82%的人表示有; 87%的人可以说出他们每天第一次喝酒的时间。80%的人表示，他们一天中第一次喝酒的时间每天变化不大。第一次饮酒的最频繁时间是09：00 - 11：00，并且与受试者的睡眠-觉醒时间（醒来时间与第一次饮酒冲动时间之间的延迟为3：45 +/- 3：30）和午餐或晚餐时间无关。这种节律性似乎是酒精依赖综合征的相关标准。
Loss of control over drinking and the craving for alcohol are cardinal signs of alcohol dependence. Our clinical practice indicates that these cravings do not occur randomly during the day, but at the same times each day for the same patient. To validate this hypothesis that alcohol-dependent patients have a circadian rhythmic craving in their desire for their first drink of the day, we asked 217 persons diagnosed as alcohol-dependent according to DSM-IV criteria to complete a questionnaire that surveyed whether this craving occurred at a fixed time each day. Of the respondents, 82% reported it did; 87% of them could state the time of day they consumed their first daily drink. and 80% reported that the time of their first drink of the day did not vary much from one day to the next. The most frequent time of consuming the first drink of alcohol was between 09:00 and 11:00h, and it was independent of the subjects' sleep-wake routine (the delay between the hours of wake-up and the time of the first urge for alcohol was 3:45 +/- 3:30h) and lunch or dinner time. This rhythmicity seems to be a pertinent criterion for alcohol dependence syndrome.