Multifunctional Hydrogel Patch with Toughness, Tissue Adhesiveness, and Antibacterial Activity for Sutureless Wound Closure
Multifunctional Hydrogel Patch with Toughness, Tissue Adhesiveness, and Antibacterial Activity for Sutureless Wound Closure
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DOI：
10.1021/acsbiomaterials.9b00130
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发表时间：
2019-05-01
影响因子：
5.8
通讯作者：
Wang, Lianyong
中科院分区：
文献类型：
--
作者：
Du, Xinchen;Wu, Le;Wang, Lianyong
多功能水凝胶贴片具有高韧性、优异的粘附性和良好的抗菌效果，是一种非常理想的手术材料。本研究以贻贝为灵感，开发了一种由聚乙二醇二丙烯酸酯/季铵盐壳聚糖/单宁酸（PEGDA/QCS/TA）组成的新型水凝胶贴剂。在体外和体内系统地评价了水凝胶贴片的物理和生物特性。结果表明，该水凝胶贴片结构紧凑，溶胀率低，力学性能坚韧，对金黄色葡萄球菌和大肠杆菌具有良好的抑菌活性，对多种底物具有良好的干湿粘附能力。水凝胶贴片也可在体内降解和吸收，可作为无缝合线材料用于伤口闭合。这些结果表明，具有多种功能的PEGDA/QCS/TA水凝胶贴片在生物医学领域具有巨大的应用潜力。
A multifunctional hydrogel patch with a combination of high toughness, superior adhesion, and good antibacterial effect is a highly desired surgical material. In this study, we developed a novel hydrogel patch composed of poly(ethylene glycol) diacrylate/quaternized chitosan/tannic acid (PEGDA/QCS/TA) based on mussel-inspired chemistry. The physical and biological properties of the hydrogel patch were systematically evaluated in vitro and in vivo. The results indicated that this hydrogel patch possessed compact microstructure, low swelling ratio, tough mechanical properties, good antibacterial activities against S. aureus and E. coli, and excellent dry/wet adhesive ability to a wide range of substrates. The hydrogel patch could also be degraded and absorbed in vivo and used as a sutureless material for wound closure. All these findings demonstrate that the PEGDA/QCS/TA hydrogel patch with multifunctional properties has great potential for application in biomedical fields.