In Vivo Imaging of Lamina Cribrosa Pores by Adaptive Optics Scanning Laser Ophthalmoscopy
In Vivo Imaging of Lamina Cribrosa Pores by Adaptive Optics Scanning Laser Ophthalmoscopy
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DOI：
10.1167/iovs.11-7536
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发表时间：
2012-06-01
影响因子：
4.4
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Akagi, Tadamichi;Hangai, Masanori;Yoshimura, Nagahisa
目的.目的：利用自适应光学扫描激光检眼镜（AOSLO）系统对青光眼患者筛板表面孔进行观察和评估。比较彩色视盘照相、无AO扫描激光检眼镜（SLO）和AOSLO检查的板层孔数量。在AOSLO图像中检查孔面积和伸长指数与眼部参数的相关性，如平均偏差、椎间盘面积、杯/盘比、椎间盘椭圆度指数、眼内压（IOP）和眼轴长度。40例受试者的40只眼（20例正常眼和20例青光眼眼）入组。与其他成像方法相比，AOSLO提供了质量更好的层状孔隙图像，并且在26名受试者中，AOSLO图像中的可见孔隙数量显著高于其他成像方法（彩色圆盘照片[P < 0.001]和无AO图像的SLO [P < 0.001]）。当对40名使用AOSLO的受试者进行比较时，昏迷受试者的孔隙面积显著大于正常受试者（P = 0.031），但伸长指数则不是。在正常受试者中，孔面积与眼轴长度（P = 0.008）显著相关，在青光眼受试者中，孔面积与未经治疗的IOP显著相关（P = 0.002），在所有受试者中，孔面积与眼轴长度（P = 0.001）和杯/盘比（P = 0.012）显著相关。通过多元回归分析，发现正常人眼轴长度与孔面积显著相关，（β = 0.684，P = 0.001）和受试者总数青光眼组（β = 0.496，P < 0.001）和未治疗组（β = 0.506，P = 0.023）和总受试者（β = 0.331，P = 0.014）的IOP。AOSLO是用于评估层状孔形态的有用成像技术。层流孔面积可能受轴向长度和IOP的影响。（Invest Ophthalmol维斯科学。2012;53：4111-4119）DOI：10.1167/iovs.11-7536
PURPOSE. To visualize and assess the surface-level pores of the lamina cribrosa in patients with glaucoma by using a prototype adaptive optics scanning laser ophthalmoscopy (AOSLO) system.METHODS. The numbers of laminar pores were compared between color disc photography, scanning laser ophthalmoscopy (SLO) without AO, and AOSLO. The pore area and elongation index were examined for correlation with ocular parameters such as the mean deviation, disc area, cup/disc ratio, disc ovality index, intraocular pressure (IOP), and axial length in the AOSLO images.RESULTS. The 40 eyes (20 normal and 20 glaucomatous) of 40 subjects were enrolled. The AOSLO provided laminar pore images of better quality than other imaging methods, and the number of visible pores was significantly greater in the AOSLO images than in the other imaging methods (the color disc photographs [P < 0.001] and SLO without AO images [P < 0.001]) when compared for 26 subjects. When compared for 40 subjects using AOSLO, the pore area was significantly larger in glaucomatous subjects than in normal subjects (P = 0.031), but elongation index was not. The pore area correlated significantly with the axial length (P = 0.008) in normal subjects, with the untreated IOPs (P = 0.002) in the glaucomatous subjects, and with the axial length (P = 0.001) and cup/disc ratio (P = 0.012) in the total subjects. Via multiple regression analysis, significant correlations with pore area were found for axial length in the normal (beta = 0.684, P = 0.001) and total subjects (beta = 0.496, P < 0.001) and untreated IOP in the glaucomatous (beta = 0.506, P = 0.023) and total subjects (beta = 0.331, P = 0.014).CONCLUSIONS. AOSLO is a useful imaging technology for assessing laminar pore morphology. The laminar pore area may be affected by axial length and IOP. (Invest Ophthalmol Vis Sci. 2012;53:4111-4119) DOI:10.1167/iovs.11-7536