HINT1 is involved in the behavioral abnormalities induced by social isolation rearing
HINT1 is involved in the behavioral abnormalities induced by social isolation rearing
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HINT1参与社会隔离养育引起的行为异常
DOI：
10.1016/j.neulet.2015.08.026
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发表时间：
2015-10-21
影响因子：
2.5
通讯作者：
Gao, Cheng-ge
中科院分区：
文献类型：
--
作者：
Dang, Yong-hui;Liu, Peng;Gao, Cheng-ge
社会隔离教养方式可导致焦虑、冲动、攻击、学习记忆障碍等行为异常，这些行为异常与某些神经精神疾病患者的核心症状有关。但其潜在的病理生理机制尚不清楚。近年来的研究表明，HINT 1与多种神经精神疾病密切相关。在本研究中，SI饲养小鼠表现出抑郁样和攻击行为。此外，HINT 1蛋白水平在PFC中降低，而在HIP中升高。基于所获得的数据，我们得出结论，HINT 1参与了由社会隔离引起的行为异常，并在不同的脑区发挥不同的作用。(C)由Elsevier爱尔兰有限公司出版。
Social isolation (SI) rearing has been demonstrated to induce behavioral abnormalities like anxiety, impulsivity, aggression, and learning and memory deficits which are relevant to core symptoms in patients with some certain neuropsychiatric disorders. But the underlying pathophysiological mechanisms remain unclear. Recent studies have revealed HINT1 has close relation with diverse neuropsychiatric diseases. In this present study, the SI rearing mice exhibited depression-like and aggressive behavior. Besides, HINT1 protein levels decreased in PFC but increased in HIP. Based on the data obtained, we concluded that HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions. (C) 2015 Published by Elsevier Ireland Ltd.