IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
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DOI：
10.1093/bfgp/elm032
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发表时间：
2007-12-01
期刊：
影响因子：
--
通讯作者：
Lefranc, Marie-Paule
中科院分区：
文献类型：
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作者：
Kaas, Quentin;Ehrenmann, Francois;Lefranc, Marie-Paule
免疫球蛋白超家族（IgSF）包括免疫球蛋白（IG）、T细胞受体（TR）和具有至少一个Ig样结构域的共同特征的蛋白质。除了MHC之外，主要组织相容性复合体（MHC）超家族（MhcSF）还包含具有MHC样结构域的共同特征的蛋白质。IMGT（R），国际ImmMunoGeneTics信息系统（R）（http：imgt.cines.fr）已经建立了一个独特的编号系统和标准化的2D图形表示，或IMGT Colliers de Perles，其考虑了Ig样和MHC样结构域的结构特征。在这篇文章中，我们回顾了IMGT科学图表的IgSF（V和C型）和MhcSF（G型）域的描述规则。这些规则基于IMGT-ontology公理和概念，并且适用于序列和结构分析，无论物种、IgSF或MhcSF蛋白或链类型如何。这些IMGT Colliers de Perles特别适用于抗体工程、序列结构分析、突变位置的可视化和比较、多态性和接触分析。
The immunoglobulin superfamily (IgSF) comprises the immunoglobulins (IG), T cell receptors (TR) and proteins that have the common feature of having at least one Ig-like domain. The major histocompatibility complex (MHC) superfamily (MhcSF) comprises, in addition to the MHC, proteins which share the common feature of having Mhc-like domains. IMGT (R), the international ImMunoGeneTics information system (R) (http://imgt.cines.fr) has set up a unique numbering system and standardized 2D graphical representations, or IMGT Colliers de Perles, which take into account the structural features of the Ig-like and Mhc-like domains. In this article, we review the IMGT Scientific chart rules for the description of the IgSF (V and C types) and of the MhcSF (G type) domains. These rules are based on the IMGT-ONTOLOGY axioms and concepts and are applicable for the sequence and structure analysis, whatever the species, the IgSF or MhcSF protein, or the chain type. These IMGT Colliers de Perles are particularly useful for antibody engineering, sequence-structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis.