Frontiers of yeast metabolic engineering: diversifying beyond ethanol and Saccharomyces.
Frontiers of yeast metabolic engineering: diversifying beyond ethanol and Saccharomyces.
复制标题
DOI：
10.1016/j.copbio.2013.03.005
复制
发表时间：
2013-12
影响因子：
7.7
通讯作者：
Leqian Liu;H. Redden;H. Alper
中科院分区：
文献类型：
--
作者：
Leqian Liu;H. Redden;H. Alper
重点酵母具有理想和良好的生物加工特性。该领域正在多样化，超越乙醇和酵母。代谢工程的努力使酵母中的新增值化学品成为可能。最近的进展推动酵母作为化学品生产的平台。微生物系统提供了一种有吸引力的可再生途径来生产所需的有机分子，如燃料和化学品。虽然代谢工程领域的注意力主要集中在大肠杆菌上，但酵母是工业产品的有效宿主和生长宿主，并且具有许多突出的、生物技术上理想的天然性状。因此，最近的焦点转移到酵母作为生产宿主以取代E。杆菌因此，产品已经多样化的酵母不仅仅是乙醇。此外，非传统酵母被认为超越了酿酒酵母。本文综述了酵母代谢工程的最新进展，以生产增值化合物，包括醇，糖衍生物，有机酸，脂肪，萜烯，芳香族化合物和聚酮化合物。此外，我们还将讨论酵母代谢工程的未来发展方向。
HighlightsYeasts possess ideal and favorable bioprocessing traits.The field is diversifying beyond ethanol and Saccharomyces.Metabolic engineering efforts enable new value-added chemicals in yeasts.Recent advancements propel yeasts as a platform for chemical production.Microbial systems provide an attractive, renewable route to produce desired organic molecules such as fuels and chemicals. While attention within the field of metabolic engineering has mostly focused on Escherichia coli, yeast is a potent host and growing host for industrial products and has many outstanding, biotechnologically desirable native traits. Thus, there has been a recent shift in focus toward yeast as production hosts to replace E. coli. As such, products have diversified in yeast beyond simply ethanol. Additionally, nonconventional yeasts have been considered to move beyond Saccharomyces cerevisiae. This review highlights recent advances in metabolic engineering of yeasts for producing value-added chemical compounds including alcohols, sugar derivatives, organic acids, fats, terpenes, aromatics, and polyketides. Furthermore, we will also discuss the future direction of metabolic engineering of yeasts.