Molecular mechanism of Metabolic Syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances
Molecular mechanism of Metabolic Syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances
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DOI：
10.1111/j.1749-6632.1999.tb07793.x
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发表时间：
1999-01-01
期刊：
影响因子：
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通讯作者：
Nakamura, T
中科院分区：
文献类型：
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作者：
Matsuzawa, Y;Funahashi, T;Nakamura, T
X综合征（Syndrome X）是一种多种危险因素聚集于个体的临床综合征，是工业化国家血管疾病的共同基础。然而，X综合征的分子基础尚未阐明。我们已经使用CT扫描分析了身体脂肪分布，并表明腹腔内内脏脂肪积累的人经常有多种风险和血管疾病。因此，“内脏脂肪综合征”是与X综合征相容的临床实体。为了阐明内脏脂肪综合征的分子机制，我们采用大规模随机测序的方法对脂肪组织中的基因表达进行了分析。出乎意料;内脏脂肪表达多种分泌蛋白质的基因，包括各种生物活性物质;我们将其命名为脂肪细胞因子。其中之一，纤溶酶原激活物抑制剂-1，在积累的内脏脂肪中过量产生，可能有助于血管疾病的发展。我们还克隆了一个新的脂肪特异性基因脂联素。脂联素是一种胶原样血浆蛋白，对血管平滑肌细胞的增殖具有抑制作用;其血浆水平在肥胖症中反常地降低。脂肪细胞因子可能在X综合征疾病的发生发展中起重要作用。
Syndrome X is a clinical syndrome in which multiple risks cluster In an individual, and it is a common basis of vascular disease in the industrial countries. The molecular basis of Syndrome X, however, has not been elucidated. We have analyzed body fat distribution using CT scan and have shown that people who have accumulated intra-abdominal visceral fat frequently have multiple risks and vascular diseases. Thus, "visceral fat syndrome" is a clinical entity compatible with Syndrome X. To clarify the molecular mechanism of the disorders in visceral fat syndrome, me analyzed the expressed genes in adipose tissue by a large-scale random sequencing. Unexpectedly; visceral fat expressed a variety of the genes for secretory proteins including various bioactive substances; we designated them adipocytokines. One of them, plasminogen activator inhibitor-1, was overproduced in accumulated visceral fat and might contribute to the development of vascular disease. We have also cloned a novel adipose-specific gene named adiponectin. Adiponectin is a collagen-like plasma protein which has an inhibitory effect on proliferation of vascular smooth muscle cells; its plasma levels are paradoxically decreased in obesity. Adipocytokines may play important roles in the development of the disorders in Syndrome X.