Systemic Absorption of Retinoic Acid
Systemic Absorption of Retinoic Acid
复制标题
视黄酸的全身吸收
DOI：
10.3109/15569528909062956
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
P. Lehman
中科院分区：
文献类型：
--
作者：
T. Franz;P. Lehman
本文研究了0.05%市售乳膏剂中[I4 C]维甲酸（RA）在恒河猴和人体内的吸收。将RA以200 mg乳膏/100 cm 2皮肤的剂量应用于6只动物剃毛的背部，持续24 h。三只动物的皮肤正常，三只动物的皮肤因用0.05% RA霜预处理背部2周而产生皮炎。还将RA 100 mg/50 cm 2应用于8名人类受试者的面部10小时，其中4名为正常皮肤，4名为继发于RA预处理2周的皮炎皮肤。在这两组实验中，根据经其他途径排泄校正的放射性的尿液排泄评估吸收，发现猴正常皮肤和皮炎皮肤的RA吸收分别为剂量的9.6%和48.3%。在人体中，皮炎皮肤的影响要小得多，正常皮肤和皮炎皮肤的吸收分别为剂量的5.3%和7.2%。在皮炎皮肤，动力学反映了受损的屏障，与...
AbstractThe absorption of [I4C]retinoic acid (RA) from a commercial 0.05% cream formulation has been studied in the rhesus monkey and humans. The RA was applied to the shaved back of 6 animals for 24 hr at a dosage of 200 mg cream/100 cm2 skin. Three animals had normal skin and three had dermatitic skin produced by 2 weeks' pretreatment of the back with 0.05% RA cream. RA 100 mg/50 cm2 was also applied for 10 hr to the face of eight human subjects, four with normal skin and four with dermatitic skin secondary to 2 weeks' pretreatment with RA. In both sets of experiments, absorption was assessed from urinary excretion of radioactivity corrected for excretion via other routes.The RA absorption in the monkey was found to be 9.6% and 48.3% of the dose, respectively, for normal and dermatitic skin. In humans the effect of dermatitic skin was much less, with absorption being 5.3% and 7.2% of the dose for normal and dermatitic skin, respectively. In dermatitic skin, the kinetics reflected a damaged barrier, with...